MOTION ANALYSIS SYSTEM

运动分析系统

• 批准号: 3520393
• 负责人: MICHAEL E GOLDBERGER
• 金额: $ 16.5万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-24 至 1990-04-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520393
• 关键词: biomedical equipment purchase; body movement; cats; spinal cord injury

This proposal is for Motion Analysis equipment that will allow us to analyze the movements of animals recovering from spinal cord injury and the movements of neurons developing in tissue culture. The motion analysis system we are requesting will serve three existing research programs in our department: 1) the first concerns the nature of recovery of motor function in adult cats with spinal cord injury; we propose to use a kinematic analysis of postural reflexes, reflex locomotion and goal-directed conditioned locomotion in order to characterize quantitatively the motor patterns used by animals with spinal cord injury and determine if they are similar to normal patterns or if the animals substitute abnormal patterns 2) the second program concerns the use of embrionic tissue transplants to enhance recovery of motor function; we propose to use a quantitative kinematic analysis to compare the extent of recovery of motor function in cats with neonatal spinal injury (complete transection with and without the addition of embrionic transplant in the lesion site 3) the third program is devoted to a quantitative analysis of the growth of limbic system neurites in culture with time-lapse video microscopy; we propose to determine if specific phases of outgrowth and branching of neurites are associated with the expression of growth-related surface antigen: Limbic System Associated Protein (LAMP) which is found almost exclusively on system nuclear groups. The first program is an extension of Dr. Michael Goldberger's research; the second, Dr. Alan Tessler's and the third, Dr. Pat Levitt's. All three currently receive PHS funding. The Motion Analysis System we are requesting is required to carry out the analyses we propose to undertake and, in particular, is essential for obtaining quantitative data. The system we are requesting has the capability of carrying out kinematic analysis of motor behavior and movement of neurites in tissue culture.

该建议是针对运动分析设备的，这将使我们能够 分析从脊髓损伤中恢复的动物的运动和 神经元在组织培养中发展的运动。 运动分析 我们要求的系统将为我们的三个现有研究计划提供服务 部门：1）第一个问题是电机功能恢复的性质 在脊髓损伤的成年猫中；我们建议使用运动学 分析姿势反射，反射运动和目标指导的分析 有条件的运动，以定量表征电动机 动物患有脊髓损伤的模式，并确定它们是否是 类似于正常模式或动物替代异常模式 2）第二个程序涉及使用包含组织移植到 增强运动功能的恢复；我们建议使用定量 运动学分析以比较运动功能的恢复程度 具有新生儿脊柱损伤的猫（有和没有 在病变站点中添加包裹物移植3）第三个程序是 致力于对边缘系统神经突的生长进行定量分析 在延时视频显微镜中培养；我们建议确定是否 神经突的出生和分支的特定阶段与 与生长有关的表面抗原的表达：边缘系统相关 蛋白质（灯）几乎完全在系统核基团上。 第一个计划是迈克尔·戈德伯格（Michael Goldberger）博士的研究的扩展。这 其次，艾伦·泰斯勒（Alan Tessler）博士和第三名，帕特·莱维特（Pat Levitt）博士。 这三个 目前获得PHS资金。 我们是运动分析系统 要求进行我们建议进行的分析 而且，特别是对于获得定量数据至关重要。 这 我们要求的系统具有执行运动学的能力 分析组织培养中神经突的运动行为和运动。