CLIMBING FIBER REPRESENTATION OF THE BODY SURFACE

身体表面的攀爬纤维表示

• 批准号: 3398300
• 负责人: LEE T ROBERTSON
• 金额: $ 8.2万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3398300
• 关键词: Macaca; body regions; cats; cerebellar Purkinje cell; cerebellar cortex; cutaneous sensory nerve; electrophysiology; electrostimulus; experimental brain lesion; histology; mathematical model; model design /development; neural information processing; neuromuscular system; olivary body; sensory feedback; sensory thresholds; stereotaxic techniques; stimulus /response; touch

The proposed research is a continuation of a long-term project dedicated to the understanding of how tactile information is represented in the cerebellar cortex and nuclei as conveyed by the climbing fiber system. The proposed studies of the cerebellar cortex will examine the climbing fiber organization in lobule VII, the lateral cortex of the anterior lobe, and the flocculus in anesthetized cats. These studies will include multiple microelectrode penetrations in each animal, extracellular unit recording of a large population of Purkinje cells, and tactile stimulation of the body surface. For each climbing fiber response isolated, the following parameters will be examined: modality of the stimuli, receptive field characteristics, and location of the response. The proposed studies of the nuclear neurons will involve extracellular recording within the anterior interpositus nucleus (NIA) in anesthetized or decerebrated cats. A criterion will first be developed for the identification of climbing fiber mediated excitatory and inhibitory activity of the interpositus neurons. Various parameters of the tactile stimulation will be evaluated in conjunction with electrical stimualtion or inactivation of the inferior olivary complex. A final study will involve a detailed mapping of the NIA to reveal the proportional and spatial organization of the climbing fiber mediated representations of the body surface. An analysis of the receptive fields obtained from the cortical and NIA studies will be used to develop a mathematical model of the climbing fiber representation. An attempt will be made to determine how skin location information is encoded in different cortical regional and in the nuclear neurons. The proposed studies of the climbing system will provide (1) a completed description of the spatial distribution and proportional representation of the body surface throughout the cerebellar cortex, (2) information on how location of a stimulus point on the body surface is encoded in various cortical regions, (3) an indication of the type and extent of convergence of information from the Purkinje cells to the NIA neurons, and (4) insights on the degree of congruence of Purkinje cell and collateral inforamtion at the nuclear level. These proposed studies will permit the formulation of new therories of cerebellar function

拟议的研究是一个长期项目的延续 致力于理解触觉信息的方式 由小脑皮层和细胞核表示 攀爬纤维系统。 小脑的拟议研究 Cortex将检查Lobule VII的攀岩纤维组织， 前叶的外侧皮层，絮凝 麻醉猫。 这些研究将包括多个 每只动物，细胞外单元中的微电极穿透 记录大量浦肯野细胞和触觉 刺激身体表面。 对于每个攀登纤维的响应 隔离，将检查以下参数： 刺激，接受场特征和位置 回复。 拟议的核神经元研究将涉及 前室内核内细胞外记录 （NIA）在麻醉或解脂猫中。 标准将首先 开发用于识别攀爬纤维介导的 植物识别神经元的兴奋性和抑制活性。 将评估触觉刺激的各种参数 与电刺激或失活的结合 下橄榄络合物。 最终研究将涉及详细的 NIA的映射以揭示比例和空间 组织攀爬纤维中介的表示 身体表面。 对从 皮质和NIA研究将用于开发 攀岩纤维表示的数学模型。 一个 尝试确定皮肤位置信息如何 在不同的皮质区域和核中编码 神经元。 提议的攀岩系统研究将提供（1） 完整的空间分布和比例的描述 整个小脑的身体表面表示 皮层，（2）有关刺激点位置如何在 身体表面编码在各种皮质区域，（3） 指示信息收敛的类型和程度 从浦肯野细胞到NIA神经元，以及（4）关于 Purkinje细胞和附带Inforamtion的一致性程度 在核水平。 这些拟议的研究将允许 小脑功能的新事物的配方