EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

EPSRC 连续制造和结晶创新制造中心

• 批准号: EP/I033459/1
• 负责人: Alastair Florence
• 金额: $ 772.25万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI033459%2F1
• 关键词: EPSRC; Centre; Innovative; Manufacturing; Continuous

This proposal will establish a national multidisciplinary centre for research into crystals and powders and the challenges presented by their industrial manufacture, properties and use. Powders, particles, crystals and the molecules they are made of are important in the chemical and pharmaceutical industries as intermediate stages and final products in the manufacture of a range of materials from drugs to inks and pigments to paints to computer screens. Crucially, the structure and properties of crystals, particles and powders control the ease of manufacture, function and performance of the final product and it is therefore important to be able to make these materials reproducibly. Firstly, by understanding the ways in which the molecules, which make up the crystal pack together. Many molecules can adopt several distinct crystal forms by packing together in different ways, which can dramatically affect physical properties despite the fact the same molecule is present. It is vital to control this during crystal formation since the wrong form could for example, affect the amount of drug released by a tablet into the body after it is swallowed. Secondly as the crystal grows its size (micrometres or millimetres), shape, or morphology (flat or round) is critical for some applications especially when many crystal particles come together in a powder and impact on the ease with which the material is subsequently manufactured into a paint or ink for example. These challenges are critical as currently manufacturers struggle with crystal formation and control of their particle and powder properties due to the traditional batch methods they employ. To tackle these problems the Centre aims to revolutionise current processes by researching exciting new continuous methods of crystal formation and particle and powder production applicable to current but importantly also future products such as nanomaterials. In addition the Centre will explore how established methods for molecule synthesis are best integrated with continuous crystallisation processes and how continuously manufactured crystals are isolated, dried and transferred into subsequent formulation and final product manufacturing stages whilst preserving their carefully optimised properties. To maximize these technology changes the Centre must also understand the impact that such a transformation will have on the way companies approach this aspect of their business. This will ensure that the maximum economic potential is effectively exploited. To achieve this the Centre consists of a multidisciplinary team of 14 outstanding researchers from 7 leading Universities covering the country from Glasgow, to Edinburgh, to Cambridge, to Bath. In addition industrial support, interest and input (2 million) will be provided from 3 major pharmaceutical companies and many small technology driven companies within the UK. This provides a combination of academic and industrial expertise ranging from chemistry and chemical engineering to pharmacy and systems management capable of powerfully attacking the issues from many angles. The Centre's aim is to deliver new continuous manufacturing technologies with improved performance in a range of areas. Control of crystal formation and particle and powder properties is critical, however a key goal will also be the development of simpler and faster technologies. Such a combination will permit quicker product development and cheaper, cleaner and greener manufacturing processes. The Centre will deliver these technologies to the UK chemical and pharmaceutical industry thus maintaining this sector at the international forefront of product development and manufacture with obvious national economic benefits in terms of jobs and income. National and international benefits will also arise through better and new medicines and improved and new consumer products, which will assist the global community.

该提案将建立一个国家多学科中心，研究晶体和粉末及其工业制造、性能和使用带来的挑战。粉末、颗粒、晶体及其构成的分子在化学和制药工业中非常重要，作为制造从药物到墨水、颜料、油漆到计算机屏幕等一系列材料的中间阶段和最终产品。至关重要的是，晶体、颗粒和粉末的结构和性质控制着最终产品的制造难易程度、功能和性能，因此能够可重复地制造这些材料非常重要。首先，了解构成晶体的分子堆积在一起的方式。许多分子可以通过以不同方式堆积在一起而采用几种不同的晶体形式，尽管存在相同的分子，但这仍会极大地影响物理性质。在晶体形成过程中控制这一点至关重要，因为错误的形式可能会影响吞咽后片剂释放到体内的药物量。其次，随着晶体的生长，其尺寸（微米或毫米）、形状或形态（扁平或圆形）对于某些应用至关重要，尤其是当许多晶体颗粒聚集成粉末时，并影响材料随后制造成的难易程度。例如油漆或墨水。这些挑战至关重要，因为目前制造商由于采用传统的批量方法，在晶体形成以及颗粒和粉末特性的控制方面遇到了困难。为了解决这些问题，该中心旨在通过研究令人兴奋的新型连续晶体形成方法以及适用于当前但重要的是未来产品（例如纳米材料）的颗粒和粉末生产来彻底改变当前的工艺。此外，该中心还将探索如何将现有的分子合成方法与连续结晶过程最好地结合起来，以及如何将连续制造的晶体分离、干燥并转移到后续配方和最终产品制造阶段，同时保留其精心优化的特性。为了最大限度地发挥这些技术变革，中心还必须了解这种变革将对公司处理其业务这方面的方式产生影响。这将确保有效地发挥最大的经济潜力。为了实现这一目标，该中心由来自格拉斯哥、爱丁堡、剑桥、巴斯等全国 7 所顶尖大学的 14 名杰出研究人员组成的多学科团队组成。此外，英国境内的 3 家主要制药公司和许多小型技术驱动型公司将提供工业支持、利息和投入（200 万）。这提供了从化学和化学工程到制药和系统管理的学术和工业专业知识的结合，能够从多个角度有力地解决问题。该中心的目标是提供新的连续制造技术，并在一系列领域提高性能。晶体形成以及颗粒和粉末特性的控制至关重要，但关键目标也将是开发更简单、更快的技术。这种结合将实现更快的产品开发以及更便宜、更清洁和更环保的制造工艺。该中心将向英国化学和制药行业提供这些技术，从而使该行业保持在产品开发和制造的国际前沿，并在就业和收入方面带来明显的国家经济效益。更好的新药品以及改进的新消费品也将给国家和国际带来好处，这将为国际社会提供帮助。

项目成果

Structure and stability of two polymorphs of creatine and its monohydrate

• DOI: 10.1039/c4ce00508b
• 发表时间: 2014-01-01
• 期刊: CRYSTENGCOMM
• 影响因子: 3.1
• 作者: Arlin, Jean-Baptiste;Bhardwaj, Rajni M.;Florence, Alastair J.
• 通讯作者: Florence, Alastair J.

Modelling of artefacts in estimations of particle size of needle-like particles from laser diffraction measurements

• DOI: 10.1016/j.ces.2016.10.031
• 发表时间: 2017-02-02
• 期刊: CHEMICAL ENGINEERING SCIENCE
• 影响因子: 4.7
• 作者: Agimelen, Okpeafoh S.;Mulholland, Anthony J.;Sefcik, Jan
• 通讯作者: Sefcik, Jan

Continuous Crystallization of Paracetamol (Acetaminophen) Form II: Selective Access to a Metastable Solid Form

• DOI: 10.1021/acs.cgd.6b01831
• 发表时间: 2017-05-01
• 期刊: CRYSTAL GROWTH & DESIGN
• 影响因子: 3.8
• 作者: Agnew, Lauren R.;McGlone, Thomas;Wilson, Chick C.
• 通讯作者: Wilson, Chick C.

Estimation of particle size distribution and aspect ratio of non-spherical particles from chord length distribution

• DOI: 10.1016/j.ces.2014.11.014
• 发表时间: 2015-02-17
• 期刊: CHEMICAL ENGINEERING SCIENCE
• 影响因子: 4.7
• 作者: Agimelen, Okpeafoh S.;Hamilton, Peter;Mulholland, Anthony J.
• 通讯作者: Mulholland, Anthony J.

Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries

晶体浆料高剪切湿磨过程中晶体尺寸和形状分布的多传感器在线测量

• DOI: 10.1016/j.apt.2018.09.003
• 发表时间: 2018
• 期刊: Advanced Powder Technology
• 影响因子: 5.2
• 作者: Agimelen O