ASSESSMENT OF CAROTID ATHEROSCLEROSIS WITH 3D ULTRASOUND

用 3D 超声评估颈动脉粥样硬化

• 批准号: 3357185
• 负责人: ROBERT H SELZER
• 金额: $ 19.83万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357185
• 关键词: angiography; atherosclerosis; carotid artery; computer program /software; human subject; image processing; ultrasonography

DESCRIPTION: (Adapted from the application) This is a proposal to improve the utility of 2-D ultrasound imaging for use in clinical trials and cardiovascular epidemiology. The investigators will acquire B-mode images with commercially available ultrasound scanning equipment augmented with a spatial locator device. Computer software will be developed to combine multiple B-mode images into a three-dimensional ultrasound image of the deep wall of the vessel. The lumen and media/adventitia boundaries will be located in the composite image and a three dimensional map of wall thickness generated. From this map, areas of wall thickening will be localized and atherosclerosis measures such as size and distribution of discrete lesions and the extent of wall thickening above a specified threshold will be computed. Accuracy of lesion assessment will be estimated from phantom studies and overall precision of the method from repeat human scans. Twenty individuals participating in an on-going clinical atherosclerosis regression trial will receive ultrasound scans with a commercially available instrument at six month intervals for a period of 24 months and the computer method will be used to determine changes in wall thickness and lesion size.

描述：（从应用程序改编）这是改进的建议 2-D超声成像用于临床试验和 心血管流行病学。 调查人员将获取B模式图像 带有市售的超声扫描设备，增强了 空间定位器设备。 将开发计算机软件以组合 多个B模式图像中的三维超声图像 船只的深墙。 管腔和媒体/院里边界将是 位于复合图像和壁的三维图中 产生的厚度。 从这张地图中，壁厚的区域将是 局部和动脉粥样硬化措施，例如大小和分布 离散病变和指定上方的壁增厚的程度 将计算阈值。 病变评估的准确性将是 根据幻影研究估计和该方法的总体精度 重复人类扫描。 二十个人参加了一个正在进行的 临床动脉粥样硬化回归试验将接受超声扫描 以六个月的间隔提供商业仪器 24个月的周期和计算机方法将用于确定 壁厚和病变大小的变化。