CAROTID IMT SCREENING WITH A PORTABLE ULTRASOUND SYSTEM

使用便携式超声系统进行颈动脉 IMT 筛查

• 批准号: 6183440
• 负责人: ROBERT H SELZER
• 金额: $ 35.84万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6183440
• 关键词: atherosclerosis; bioimaging /biomedical imaging; biomedical equipment development; cardiovascular disorder diagnosis; carotid artery; clinical biomedical equipment; clinical research; computer assisted diagnosis; diagnosis design /evaluation; diagnosis quality /standard; digital imaging; human subject; image enhancement; mass screening; statistics /biometry; videotape /videodisc

DESCRIPTION: (Adapted from Investigator's Abstract) The main objectives of the original application were as follows: 1) to re-program the Prosound carotid IMT assessment method to utilize more compact hardware; and 2) to test longitudinal transducer positioning with stacking (modified Beach method) of the carotid artery and jugular vein to obtain more reproducible IMT measurements have been completed. Technology for on-line display of baseline and real-time images and a mechanical rotation transducer holding device have been developed. The investigators have reduced IMT measurement variability by 50% (coefficient of variation, CV, from 3.25% to 1.60%) using these newest developments to acquire IMT images. Preliminary data indicate that using the transducer holding device with head in-line anatomical body positioning and lateral scanning, reduces the IMT measurement CV to 0.58%. Additionally, they have developed prototypal software for multiple sequential-frame IMT analysis over full cardiac cycles which further reduces IMT measurement variability. As a continuation of their findings, the investigators propose to develop a carotid artery IMT assessment technique that will be more reproducible than any currently available technique with special application to multicenter image acquisition by: 1) more fully automating IMT image acquisition by developing an electro/mechanical rotational transducer device; and 2) developing an easily deployed automated multiple sequential-frame IMT analysis system. These improvements will effectively maximize IMT measurement reproducibility for a single center and are easily applied to a multicenter clinical setting. A major goal of this continuation application is to deploy their newest and most highly reproducible IMT image acquisition and processing methodology across three clinical sites and determine the cross-sectional and longitudinal variability of this new standardized automated methodology for measuring IMT in a multicenter setting. The investigators state that this methodology has important implications since reduced IMT measurement variability will result in reduced sample size requirements and costs for conducting multicenter studies.

描述：（根据研究者的摘要进行了改编）主要目标 原始应用的如下：1）重新编程 利用更紧凑的硬件的颈动脉IMT评估方法； 2）用堆叠测试纵向换能器定位（修改 颈动脉和颈静脉的海滩法）获得更多 可再现的IMT测量已完成。 在线技术 显示基线和实时图像以及机械旋转 已开发了换能器保持装置。 调查人员有 IMT测量变异性降低了50％（变异系数，简历， 从3.25％到1.60％）使用这些最新的发展来获取IMT 图像。 初步数据表明使用传感器保持 具有头部在线解剖体定位和横向扫描的设备， 将IMT测量简历降低到0.58％。此外，他们已经发展 用于完整的多个顺序框架IMT分析的原型软件 心脏周期进一步降低了IMT测量变异性。 作为 延续他们的发现，调查人员建议开发 颈动脉IMT评估技术将更可重复 比当前有特殊应用的任何当前可用技术 多中心图像采集：1）更完全自动化的IMT图像 通过开发电/机械旋转传感器来获取 设备; 2）开发易于部署的自动化倍数 顺序框架IMT分析系统。 这些改进将有效 最大化单个中心的IMT测量可重复性 轻松应用于多中心临床环境。 一个主要目标 继续应用程序是部署其最新且高度的 可再现的IMT图像采集和处理方法 临床部位并确定横截面和纵向 这种新的标准化自动化方法的可变性 在多中心设置中IMT。 调查人员指出这 方法学具有重要意义，因为IMT测量降低 可变性将导致样本量需求减少和成本减少 进行多中心研究。