PROSPEcT: Ecotoxicology test protocols for representative nanomaterials in support of the OECD sponsorship programme

前景：支持经合组织赞助计划的代表性纳米材料的生态毒理学测试方案

• 批准号: EP/G043140/1
• 负责人: Tamara Susan Galloway
• 金额: $ 60.81万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG043140%2F1
• 关键词: PROSPEcT; Ecotoxicology; test; protocols; representative

The proposed research forms an integral part of the PROSPEcT LINK project, initiated through the 'Nanoscience through Engineering to Application' programme. The project aims to provide a direct contribution to the global safety assessment of nanomaterials described by the OECD Working Party on Manufactured Nanomaterials (WPMN). The LINK project will develop essential and seminal test methods and data on two agreed nanomaterials that are of particular commercial relevance to the UK. The project will innovate the scientific foundations for adapting or creating test methods that enable the ecotoxicological hazard assessment of nanomaterials. Both particles (i.e. CeO2 and ZnO) are part of a list of 14 nanomaterials, identified as commercially relevant to the global economic impact of nanotechnology. Furthermore, the development of methods to characterize CeO2 and ZnO nanomaterials in concert with parallel and coordinated development for other nanomaterials across the OECD testing program will enablethe future establishment of QSARs (Quantitative Structure Activity Relationships) for predictive safety evaluations of novel nanomaterials.The resulting scientific advancement will help to secure an economic future for the commercialisation of nanotechnologies in and by the UK and provide crucial UK leadership and information to the OECD's global programme on nanomaterials safety assessment.

拟议的研究是 PROSPECT LINK 项目的一个组成部分，该项目是通过“从工程到应用的纳米科学”计划发起的。该项目旨在为经合组织人造纳米材料工作组 (WPMN) 描述的纳米材料全球安全评估做出直接贡献。 LINK 项目将为两种商定的纳米材料开发基本且具有开创性的测试方法和数据，这两种材料对英国具有特殊的商业意义。该项目将为适应或创建能够对纳米材料进行生态毒理学危害评估的测试方法奠定创新的科学基础。这两种颗粒（即 CeO2 和 ZnO）均属于 14 种纳米材料清单的一部分，被确定为与纳米技术的全球经济影响具有商业相关性。此外，开发表征 CeO2 和 ZnO 纳米材料的方法，与 OECD 测试计划中其他纳米材料的并行和协调开发相结合，将有助于未来建立 QSAR（定量结构活性关系），用于新型纳米材料的预测安全性评估。这一进展将有助于确保英国纳米技术商业化的经济未来，并为经合组织纳米材料安全评估全球计划提供重要的英国领导力和信息。

项目成果

Cerium oxide nanoparticles induce oxidative stress in the sediment-dwelling amphipod Corophium volutator.

氧化铈纳米颗粒会在沉积物中的片脚类 Corophium v​​olutator 中引起氧化应激。

• DOI: http://dx.10.3109/17435390.2015.1088587
• 发表时间: 2016
• 期刊: Nanotoxicology
• 影响因子: 5
• 作者: Dogra Y

Tracing engineered nanomaterials in biological tissues using coherent anti-Stokes Raman scattering (CARS) microscopy - A critical review.

使用相干反斯托克斯拉曼散射 (CARS) 显微镜追踪生物组织中的工程纳米材料 - 批判性评论。

• DOI: http://dx.10.3109/17435390.2014.991773
• 发表时间: 2015
• 期刊: Nanotoxicology
• 影响因子: 5
• 作者: Goodhead RM

Silver nanoparticles: behaviour and effects in the aquatic environment.

银纳米颗粒：水生环境中的行为和影响。

• DOI: 10.1016/j.envint.2010.10.012
• 发表时间: 2011-02-01
• 期刊: Environment international
• 影响因子: 11.8
• 作者: Julia Fabrega;S. Luoma;C. Tyler;T. Galloway;J. Lead
• 通讯作者: J. Lead

Sequestration of zinc from zinc oxide nanoparticles and life cycle effects in the sediment dweller amphipod Corophium volutator.

氧化锌纳米颗粒中锌的封存以及沉积物端足类 Corophium v​​olutator 中的生命周期效应。

• DOI: 10.1021/es202570g
• 发表时间: 2012-01-17
• 期刊: Environmental science & technology
• 影响因子: 11.4
• 作者: Julia Fabrega;R. Tantra;A. Amer;B. Stolpe;J. Tomkins;T. Fry;J. Lead;C. Tyler;T. Galloway
• 通讯作者: T. Galloway

Sublethal toxicity of nano-titanium dioxide and carbon nanotubes in a sediment dwelling marine polychaete.

沉积物中的纳米二氧化钛和碳纳米管的亚致死毒性海洋多毛类动物。

• DOI: 10.1016/j.envpol.2009.11.013
• 发表时间: 2010-05-01
• 期刊: Environmental pollution
• 影响因子: 8.9
• 作者: T. Galloway;C. Lewis;Ida Dolciotti;B. Johnston;J. Moger;F. Regoli
• 通讯作者: F. Regoli