RISK FACTORS FOR ASTHMA IN LABORATORY ANIMAL ALLERGY

实验室动物过敏导致哮喘的危险因素

基本信息

批准号：
3341563
负责人：
Peyton A Eggleston
金额：
$ 27.08万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-07-01 至 1991-06-30
项目状态：
已结题

项目摘要

The primary objective of this prospective, multidisciplinary study is to identify risk factors which predispose individuals to develop asthma and other manifestations of allergic disease on exposure to laboratory animals in the workplace. This proposal is to continue a study which was originally funded for 3 years. Specific objectives relate to two major questions under investigation. First, what are the factors which increase the risk of allergic asthma, as measured by relative risk? Factors of potential importance include: airway hyperreactivity; personal or family history of allergy or asthma; skin test sensitivity to animal or other aeroallergens; IgE and IgG antibody levels to animal allergens; demographic and psychosocial factors; and workplace exposure levels to specific respirable animal allergens. Second, what is the natural history of the development of allergy and asthma to lab animals? How do changes in factors such as exposure to animals, airway hyperreactivity, specific IgE and IgG, skin test reactivity, and symptoms relate to one another and to other factors, in a temporal sense in the development of disease? These questions are being addressed in a longitudinal study of 500 research lab workers with minimal prior exposure to the animals and who do not have asthma to the animals at the time of entering this longitudinal study. Subjects are evaluated at 6-month intervals for at least 30 months, with the following: personal interviews; tests for immunologic reactivity (skin tests, serum IgE and IgG antibodies); and tests of airway reactivity (bronchoprovocation with mechalyl). The degree of exposure to animal allergens is quantitated by aeroallergen sampling of workplace and personal breathing zone air, and by Work Diaries. Laboratory animal allergy provides an excellent model of occupational asthma, and increasingly important problem. An improved understanding of mechanisms and risk factors will contribute to successful prevention not only of asthma and allergy to lab animals but also of allergic disorders not limited to the occupational environment.

这项前瞻性、多学科研究的主要目标是识别导致个体罹患哮喘的危险因素，并接触实验动物引起的过敏性疾病的其他表现在工作场所。本提案旨在继续一项研究最初资助3年。具体目标涉及两个主要方面正在调查的问题。首先，哪些因素会增加患过敏性哮喘的风险？通过相对风险来衡量？潜在重要因素包括：气道高反应性；个人或家族过敏或哮喘病史；对动物或其他空气过敏原进行皮试敏感性； IgE 和 IgG 动物过敏原的抗体水平；人口和社会心理因素；以及工作场所对特定可吸入动物过敏原的暴露水平。其次，过敏症发展的自然史是怎样的？实验动物哮喘？暴露等因素如何变化动物、气道高反应性、特异性 IgE 和 IgG、皮试反应性和症状彼此相关并与其他因素相关，在一种疾病发展的时间意义？这些问题正在通过 500 项研究的纵向研究得到解答之前与动物接触最少且没有接触过动物的实验室工作人员在进入这项纵向研究时，动物患有哮喘。受试者每 6 个月接受一次评估，持续至少 30 个月，其中以下：个人访谈；免疫反应性测试（皮肤测试、血清 IgE 和 IgG 抗体）；和气道反应性测试（用甲酰进行支气管激发）。接触动物的程度通过对工作场所和个人进行空气过敏原采样来定量过敏原呼吸区空气，以及工作日记。实验动物过敏提供了一个很好的职业模型哮喘，一个日益重要的问题。更好的理解机制和风险因素将有助于成功预防，而不是不仅涉及哮喘和对实验动物过敏，还涉及过敏性疾病不限于职业环境。