UVR8 photoreceptor action

UVR8光感受器作用

• 批准号: BB/Y006054/1
• 负责人: Gareth Islwyn Jenkins
• 金额: $ 74.34万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY006054%2F1
• 关键词: UVR8; photoreceptor; action

Ultraviolet-B (UV-B) radiation is a minor but very energetic component of sunlight. Exposure to UV-B wavelengths (280-315 nm) has numerous effects on plants, including changes in metabolism and development that impact biochemical composition, plant architecture and defence against pests and pathogens. The effects of UV-B radiation are due to its ability to regulate the expression of numerous plant genes, including those involved in metabolic pathways, UV-protection, morphogenesis and defence. It is therefore important to understand how UV-B radiation is perceived by plants and how it initiates responses. A pivotal component involved in these processes is a protein called UVR8, which acts as a photoreceptor to detect UV-B radiation. UVR8 physically interacts with several other proteins, including a number of proteins that regulate gene expression, to initiate responses to UV-B in plants, but also with proteins that repress UVR8 activity. However, we have little understanding of the molecular mechanisms that determine how UVR8 interacts differentially with these proteins to control its activity, although we know that it involves a particular region of the UVR8 protein. The basis of this project is that we have recently identified a mechanism that is important in regulating which proteins interact with UVR8 to modulate responses. Hence the aim of this project is to gain a more complete understanding of this mechanism and how it affects UVR8 action. In addition to establishing the molecular basis of UVR8 action, the information gained opens up the possibility of identifying variants of UVR8 and its interacting proteins that would allow manipulation of UVR8 activity in crop plants to enhance aspects of quality and productivity.

紫外线 B (UV-B) 辐射是阳光中含量较少但能量非常高的成分。暴露于 UV-B 波长（280-315 nm）对植物有多种影响，包括影响生化成分、植物结构以及对害虫和病原体的防御的新陈代谢和发育变化。 UV-B 辐射的影响是由于它能够调节许多植物基因的表达，包括那些涉及代谢途径、紫外线防护、形态发生和防御的基因。因此，了解植物如何感知 UV-B 辐射以及它如何引发反应非常重要。这些过程中涉及的一个关键成分是一种名为 UVR8 的蛋白质，它充当检测 UV-B 辐射的光感受器。 UVR8 与其他几种蛋白质发生物理相互作用，包括许多调节基因表达的蛋白质，以启动植物对 UV-B 的反应，但也与抑制 UVR8 活性的蛋白质相互作用。然而，我们对决定 UVR8 如何与这些蛋白质差异性相互作用以控制其活性的分子机制知之甚少，尽管我们知道它涉及 UVR8 蛋白质的特定区域。该项目的基础是我们最近发现了一种对于调节哪些蛋白质与 UVR8 相互作用以调节反应非常重要的机制。因此，该项目的目的是更全面地了解该机制及其如何影响 UVR8 的作用。除了建立 UVR8 作用的分子基础外，获得的信息还为识别 UVR8 及其相互作用蛋白的变体提供了可能性，这些变体将允许操纵作物中的 UVR8 活性，以提高质量和生产力。