TEMPORARY SILICON CONNECTION IN CARBOHYDRATE CHEMISTRY

碳水化合物化学中的临时硅连接

• 批准号: 3303055
• 负责人: GILBERT STORK
• 金额: $ 13.16万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3303055
• 关键词: chemical reaction; chemical synthesis; disaccharides; furans; glycosides; organosilicon compound; silanes; stereochemistry

The thread that links this proposal for what we consider to be a breakthrough in carbohydrate chemistry is the control available via the temporary silicon tether, a general method of control we have developed. The first part of this proposal deals with a general method for the construction of C-glycosides with complete stereospecificity. The preliminary results we have obtained make it clear that this will be a very important method for the synthesis of these substances which are involved in areas as diverse as antiviral substances and polyether antibiotics. We believe that the method will prove to be equally successful in making deoxy C-furanosides which are of interest in anti AIDS drugs, inter alia. Deoxyglycosides should also present no particular problems. The second part of the proposal deals with a proposal for the stereospecific construction of disaccharides--and eventually of polysaccharides. If preliminary results hold up, we believe it will prove of considerable importance.

将该提案链接到我们认为的主题的线程 碳水化合物化学的突破是通过控制 临时硅系链，我们拥有的一种通用控制方法 发达。 该提案的第一部分涉及一般性内容 一种完整的C-糖苷的构建方法 立体专一性。 我们得到的初步结果 显然这将是一种非常重要的合成方法 这些物质涉及抗病毒等多种领域 物质和聚醚抗生素。 我们认为该方法 将被证明在制造脱氧 C-呋喃糖苷方面同样成功 其中尤其对抗艾滋病药物感兴趣。 脱氧糖苷也不应该出现任何特殊问题。 该提案的第二部分涉及关于 二糖的立体定向结构——最终 多糖。 如果初步结果成立，我们相信 证明相当重要。