SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS

生物活性天然产物的合成

• 批准号: 2166066
• 负责人: GILBERT STORK
• 金额: $ 31.37万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2166066
• 关键词: biological products; curare; drug design /synthesis /production; paclitaxel; stereochemistry; strychnine

This proposal is to continue the long-term support which has been the major financial basis of the work on total synthesis and methodology which has been the main focus of our research at Columbia for many years. Our main goal has been to develop synthetic methods to achieve desired transformations in a way that would also control the regio- and stereochemistry of the process. Eventually, of course, these methods are applied to the total synthesis of biologically interesting molecules. Over the years the specific targets have covered many structural types, such as steroids, indole alkaloids, prostaglandins, etc. At present, and not surprisingly, a major effort is toward the stereocontrolled total synthesis of the anticancer taxol. We hope, naturally, that our contributions will extend, beyond whatever specific target, to long- lasting advances in synthetic methodology of some generality.

该提议是为了继续长期以来的支持 全合成和方法学工作的主要财务基础 多年来，这一直是我们在哥伦比亚大学研究的主要焦点。 我们的主要目标是开发合成方法以实现所需的 转变的方式也将控制区域和 该过程的立体化学。 当然，最终这些方法都是 应用于生物学上感兴趣的分子的全合成。 多年来的具体目标已涵盖多种结构类型， 如类固醇、吲哚生物碱、前列腺素等。目前， 毫不奇怪，主要的努力是为了立体控制总 抗癌紫杉醇的合成。 我们自然希望我们的 贡献将超越任何具体目标，延伸到长期 具有一定普遍性的合成方法的持久进展。