SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS

生物活性天然产物的合成

• 批准号: 3267870
• 负责人: GILBERT STORK
• 金额: $ 31.32万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3267870
• 关键词: 25 hydroxycholecalciferol; anthracyclines; antineoplastic antibiotics; central nervous system; drug design /synthesis /production; eicosanoid metabolism; erythromycin; fatty acid biosynthesis; indoles; lactones; neurotoxins; quinine; reserpine; rifamycins; stereochemistry; strychnine; tetracyclines

Development of a stereospecific general approach to polypropionate macrocyclic antibiotics such as maytansine, rifamycin, erythromycin. General synthetic routes to the histrionicotoxins. Synthesis of hydroxyvitamin D3. Synthesis of the tetracyclines synthesis of indole alkaloids such as reserpine strychnine and certain curar alkaloids. Stereospecific synthesis of Quinine.

开发聚丙酸酯的立体特异性通用方法 大环抗生素如美登素、利福霉素、红霉素。 剧毒毒素的一般合成路线。 合成 羟基维生素D3。 四环素类吲哚的合成 生物碱，例如利血平士的宁和某些箭豆生物碱。 奎宁的立体定向合成。