OpenBioMAPS: shared tools for accelerating UK bio-manufacturing

OpenBioMAPS：加速英国生物制造的共享工具

• 批准号: BB/Y007808/1
• 负责人: James Haseloff
• 金额: $ 129.39万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY007808%2F1
• 关键词: OpenBioMAPS; shared; tools; accelerating; UK

We will develop an ecosystem of open source tools to accelerate adoption of engineering biology capabilities in the UK biomanufacturing sector. IP protection allows bioenterprises freedom to operate and prevent unfair competition. However, most engineered biosystems require many "nuts- and-bolts" parts. Start-ups and SMEs, who are critical to advance UK clean growth targets through novel sustainable manufacturing processes, have limited access compared to established companies and may need to negotiate a thicket of licences.Open licensing can reduce transaction costs in adoption of new innovations by SME's, as we demonstrated in the OpenPlant research centre. We will now expand our previous work developing DNA toolkits for plant and microbial engineering (openplant.org), legal tools for materials sharing (OpenMTA.org) and training for engineering and biology (e.g. biomaker.org). We plan to develop (i) biological engineering tools for UK bio-manufacturing companies including prototypes for microbial fermentation and plant chloroplast-based bioproduction and opportunities for commercialisation, (ii) training for academics and industry scientists to develop skills at the interface of biology and engineering; iii) mini-projects across the UK engineering biology community to promote further development of tools. Overall, this will build capacity for adoption of open source tools, principles and development practices.Open source tools are pervasive in computing, industry estimates suggest that 80-90% of new apps are built from existing components, mostly open source. Biomanufacturing could benefit from similar reusability. We aim to establish a flagship platform to accelerate the UK biomanufacturing enterprise, and a possible springboard for establishing an Open Source Program Office (OSPO) for UK engineering biology, mirroring successful tech industry OSPOs.

我们将开发一个开源工具的生态系统，以加速英国生物制造业的工程生物学能力。 IP保护允许生物伦理自由运营和防止不公平的竞争。但是，大多数工程生物系统都需要许多“坚果和螺栓”部分。初创企业和中小型企业对于通过新颖的可持续制造过程提高英国清洁增长目标至关重要，与成熟的公司相比，访问权限有限，并且可能需要协商一系列许可。开放许可可以降低SME采用新创新的交易成本，正如我们在开放式研究中心所证明的那样。现在，我们将扩大以前的工作，开发用于植物和微生物工程（OpenPlant.org），材料共享法律工具（OpenMTA.org）和工程和生物学培训（例如Biomaker.org）的DNA工具包。我们计划为英国生物制造公司开发（i）生物工程工具，包括用于微生物发酵的原型和基于植物叶绿体的生物生产和商业化的机会，（ii）对学者和行业科学家的培训，以在生物学和工程界面上发展技能； iii）英国工程生物学界的迷你项目，以促进工具的进一步开发。总体而言，这将增强采用开源工具，原理和开发实践的能力。开放的源工具在计算中普遍存在，行业估计表明，80-90％的新应用程序是由现有组件构建的，主要是开源的。生物制造可以受益于类似的可重复性。我们旨在建立一个旗舰平台来加速英国生物制造企业，并可能建立用于英国工程生物学的开源计划办公室（OSPO）的跳板，反映了成功的技术行业OSPOS。