How does EFR3 control insulin-stimulated plasma membrane dispersal of GLUT4?

EFR3 如何控制胰岛素刺激的 GLUT4 质膜扩散？

• 批准号: BB/X005178/1
• 负责人: Gwyn William Gould
• 金额: $ 61.4万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FX005178%2F1
• 关键词: How; does; EFR3; control; insulin; How; does; EFR3; control; insulin

All cells are surrounded by a structure called the plasma membrane. This provides protection for a cell and helps keep the environment inside the cell stable. The plasma membrane has several functions, including regulating what gets in and out of the cell, and helping the cell sense and respond to external events.Nutrients like sugars are transported across the plasma membrane by specialised proteins called 'transporters'. Understanding how these nutrient transporters are controlled is important, as depending on the conditions a cell may need to increase or decrease the rate of entry of a particular nutrient, perhaps in response to a specific cue.Our group studies how sugar (glucose) transport is regulated, and in particular how this is regulated by a hormone called insulin. Insulin plays an important role in helping keep blood sugar levels constant by controlling the rate by which sugar crosses the plasma membrane of fat and muscle. Defective glucose transport is associated with diseases such as diabetes and also some neurological disorders, hence understanding how transporter proteins are regulated may have considerable impact.Our group has uncovered a new way in which membrane transporters are controlled. We have found that insulin acts to 'disperse' glucose transporters. In the absence of insulin transporters are clustered together (rather like sheep in a pen). Insulin acts to open the gates to the pen and allow the transporters to rapidly move around in the plasma membrane so that they can function effectively and allow glucose transport.We have been able to gain some clues to how a cell does this, and here we seek to further understand how this dispersal is controlled, to ask whether this is specific for sugar transporters or if it is displayed by other nutrient transporters (or happens to all plasma membrane proteins), and we will look to understand how hormones like insulin induce a change in clustering.Our work will, we believe, be of wide interest to colleagues who study cell membrane function from both a basic biology and a translational standpoint. To address these questions, we have created a team of biologists, physicists, and electronics experts to bring their skills to bear on a common problem of fundamental importance.

所有细胞都被称为质膜的结构所包围。这为单元提供了保护，并有助于保持细胞内部稳定的环境。质膜具有多种功能，包括调节进出细胞的内容，并帮助细胞感和对外部事件的反应。糖（例如糖）通过称为“转运蛋白”的专业蛋白在质膜上运输。了解这些养分转运蛋白的控制方式很重要，因为取决于细胞可能需要增加或降低特定营养素的进入率，这可能是对特定提示的响应。胰岛素通过控制糖穿过脂肪和肌肉的质膜的速率来帮助保持血糖水平持续的重要作用。有缺陷的葡萄糖转运与糖尿病等疾病以及某些神经系统疾病有关，因此了解如何调节转运蛋白可能会产生相当大的影响。您的组发现了一种控制膜转运蛋白的新方法。我们发现胰岛素作用着“分散”葡萄糖转运蛋白。在没有胰岛素转运蛋白的情况下，聚集在一起（就像笔中的绵羊一样）。胰岛素的举动可以打开钢笔的大门，并允许转运蛋白在质膜中快速移动，以便它们可以有效地运作并允许葡萄糖运输。我们能够获得一些线索的线索，在这里我们试图进一步了解这种分散的群体，以询问该群体是否针对糖的特定于糖的特异性，是否在糖中显示了其他启动者，或者是否有其他transer transem trans trans transem nutmbrient thembrient thembrient trans nutmbrient trans（如果它是其他trans）（如果是其他trans）（如果它是其他trans）的（如果它是其他trans）的（如果是其他trans）。蛋白质），我们将旨在了解胰岛素等激素如何诱导聚类的变化。我们认为，我们的工作将对从基本生物学和翻译角度研究细胞膜功能的同事们广泛感兴趣。为了解决这些问题，我们创建了一个由生物学家，物理学家和电子专家组成的团队，以使他们的技能承担着一个普遍的重要问题。