DIRECTIONALLY SENSITIVE INPUT TO OCULOMOTOR PATHWAYS

动眼神经通路的方向敏感输入

• 批准号: 3070182
• 负责人: MICHAEL ARIEL
• 金额: $ 6.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3070182
• 关键词: Chelonia; basal ganglia; biological information processing; brain circulation; extracorporeal circulation; neural conduction; neurophysiology; oculomotor nuclei; reflex; retinal ganglion; sensorimotor system; visual pathways

Funds are requested for an ADAMHA RSDA Level II to enable the principle investigator (P.I.) to investigate the functional role that directionally sensitive (DS) cells play in visually evoked behaviors. The P.I. is in his 4th yr. as an Asst. Professor following 4 yrs. as a Postdoctoral Fellow. Now that his laboratory is established, the constraints of academia slow his immediate experimental goals as well as his long-term professional growth. This award will free the P.I. from other commitments to allow for the development of unique neuroscience approaches to the understanding of information processing and sensory-motor integration. The research goals of the P.I. and the Department of Behavior Neuroscience are directed towards an understanding of the brain's control of behavior by using current neuroscience approaches. The P.I. will draw upon the considerable neuroscience expertise of his department and the University of Pittsburgh at large to development techniques of in vitro brain neurophysiology and combine them with his approaches of pharmacology and receptive field analysis of an intact system. DS retinal ganglion cells are output neurons of the eye that respond selectively to stimuli moving only in one direction. They will be studied as a possible input to a complex brain system which stabilizes images on the retina by controlling eye position. The P.I. is currently funded to perform experiments which compare neuronal responses in the anaesthetized animal to optokinetic nystagmus (OKN) in the awake animal. Recently though, an in vitro preparation using the turtle is being developed for oculomotor research. This preparation has the unique advantage that the entire system remains intact and viable, so that DS cells in the extracorporeal brain respond to visual stimuli projected onto the attached eyes. The development of in vitro approaches to the study of these reflex behaviors require new skills for the P.I. Perfecting these techniques will produce new tools to use in investigations of the brain's control over behavior. These experiments can then involve sensory-motor integration from the cellular basis of sensory feature extraction to the convergence of sensory pathways onto motor output pathways. Stabilization of the visual image by OKN is a simple model of a sensory- motor behavior. In humans, a disorder of a related eye movement function is an indication of schizophrenia. Knowledge of oculomotor control may further OKN's diagnostic usefulness by differentiating between retinal and central control of eye movement behaviors in normal and disease states.

ADAMHA RSDA II 级需要资金，以实现该原则 调查员（P.I.）调查定向的功能作用 敏感（DS）细胞参与视觉诱发行为。 P.I.是在 他第四年了。作为助理。 4年后晋升教授。作为博士后 同胞。 现在他的实验室成立了，所面临的限制 学术界放慢了他近期的实验目标以及他的长期目标 专业成长。该奖项将释放 P.I.来自其他承诺 允许开发独特的神经科学方法 了解信息处理和感觉运动整合。 P.I. 的研究目标和行为部门 神经科学旨在了解大脑的控制 使用当前的神经科学方法来研究行为。 P.I.会画 基于他所在部门的丰富的神经科学专业知识和 匹兹堡大学致力于开发体外技术 脑神经生理学并将它们与他的方法结合起来 完整系统的药理学和感受野分析。 DS 视网膜神经节细胞是眼睛的输出神经元，可做出反应 选择性地刺激仅向一个方向移动。 他们将是 研究作为稳定复杂大脑系统的可能输入 通过控制眼睛位置在视网膜上成像。 P.I.目前是 资助进行比较神经元反应的实验 麻醉动物与清醒动物的视动眼球震颤（OKN）。 然而最近，一种使用海龟的体外制剂正在被开发出来。 为动眼神经研究而开发。 该制剂具有独特的 整个系统保持完整且可行的优点，使 DS 体外大脑中的细胞对投射的视觉刺激做出反应 到附加的眼睛上。 研究这些反射的体外方法的发展 行为需要 P.I. 的新技能。 完善这些技术 将产生用于研究大脑控制的新工具 超过行为。 这些实验可以涉及感觉运动 从感觉特征提取的细胞基础到 感觉通路与运动输出通路的融合。 OKN 稳定视觉图像是一个简单的感官模型 运动行为。 在人类中，相关眼球运动功能障碍 是精神分裂症的征兆。 动眼神经控制知识可能 通过区分视网膜，进一步提高 OKN 的诊断实用性 正常和疾病状态下眼球运动行为的中枢控制 州。