GENETIC CONTROL OF MAMMALIAN DIFFERENTIATION

哺乳动物分化的遗传控制

• 批准号: 3274650
• 负责人: SALOME G. GLUECKSOHN-WAELSCH
• 金额: $ 32.09万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3274650
• 关键词: autoimmune disorder; cell cell interaction; cell differentiation; cell fusion; chromosome deletion; cytogenetics; developmental genetics; fertility; gene complementation; genetic disorder; genetic models; genotype; histogenesis; hybrid cells; inborn metabolism disorder; lethal genes; leukocytosis; mammalian embryology; molecular pathology; newborn animals; prenatal growth disorder; spermatogenesis; tissue /cell culture

This research project deals with problems of mammalian developmental genetics. In particular it is concerned with the identification of specific genes, both structural and regulatory, which control various aspects of embryonic development and cell differentiation on levels of morphogenesis and biochemistry. Mutations in the mouse affecting development and differentiation serve as tools in these studies. The identification of genetically caused specific developmental defects provides the potential of elucidating the corresponding normal mechanisms of development and their genetic control. Particular attention centers on complex genes, e.g. the T-locus and several lethal albino deletions in the mouse. The latter appear to include a series of regulatory genes concerned specifically with the control of liver cell differentiation. Methods of genetics, developmental biology, biochemistry, somatic cell genetics, electronmicroscopy, cytology and molecular biology serve these studies. The research proposed here provides model systems for the study of birth defects and inborn errors of metabolism in humans. It opens up new views on the etiology of congenital malformations and underscores the genetic heterogeneity of conditions with similar appearances, e.g. glycogen storage diseases.

该研究项目涉及哺乳动物发育问题 遗传学。 它尤其涉及到身份识别 特定的基因，包括结构基因和调节基因，控制各种 胚胎发育和细胞分化水平的各个方面 形态发生和生物化学。 小鼠突变影响 发育和分化是这些研究的工具。 这 识别遗传引起的特定发育缺陷 提供了阐明相应正常机制的潜力 发育及其遗传控制。 特别关注的是 复杂的基因，例如T 基因座和几个致命的白化基因缺失 老鼠。 后者似乎包括一系列相关的调控基因 特别是与肝细胞分化的控制。 方法 遗传学、发育生物学、生物化学、体细胞遗传学、 电子显微镜、细胞学和分子生物学为这些研究服务。 这里提出的研究为出生研究提供了模型系统 人类新陈代谢的缺陷和先天性错误。 它开辟了新的视野 先天性畸形的病因学并强调遗传因素 具有相似外观的条件的异质性，例如糖原储存 疾病。