GENETIC CONTROL OF MAMMALIAN DIFFERENTIATION

哺乳动物分化的遗传控制

• 批准号: 3274652
• 负责人: SALOME G. GLUECKSOHN-WAELSCH
• 金额: $ 31.24万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3274652
• 关键词: animal population genetics; autoimmune disorder; cell cell interaction; cell differentiation; cell transformation; cell type; chromosome deletion; chromosome disorders; cytogenetics; developmental genetics; enzyme mechanism; gene complementation; gene mutation; genetic disorder; genetic mapping; genetic models; genotype; histogenesis; inborn metabolism disorder; laboratory mouse; lethal genes; mammalian embryology; molecular genetics; molecular pathology; prenatal growth disorder; regulatory gene; structural genes; tissue /cell culture

This research project deals with problems of mammalian developmental genetics. In particular it is concerned with the identification of specific genes, both structural and regulatory, which control various aspects of embryonic development and cell differentiation on levels of morphogenesis and biochemistry. Mutations in the mouse affecting development and differentiation serve as tools in these studies. The identification of genetically caused specific developmental defects provides the potential of elucidating the corresponding normal mechanisms of development and their genetic control. Particular attention centers on a complex of lethal albino deletion in the mouse. These appear to include regulatory genes concerned specifically with the control of liver cell differentiation. Methods of genetics, developmental biology, biochemistry, somatic cell genetics, electronmicroscopy, cytology and molecular biology serve these studies. The research proposed here provides model systems for the study of birth defects and inborn errors of metabolism in humans. It opens up new views on the etiology of congenital malformations and underscores the genetic heterogeneity of conditions with similar appearances, e.g. glycogen storage diseases and other metabolic abnormalities.

该研究项目涉及哺乳动物的问题 发育遗传学。 它特别关注的是 识别特定基因，包括结构基因和调控基因， 控制胚胎发育和细胞的各个方面 形态发生和生物化学水平上的分化。 影响发育和分化的小鼠突变 作为这些研究的工具。 基因鉴定 引起的特定发育缺陷提供了潜力 阐明相应的正常发育机制 及其基因控制。 特别关注的是 小鼠致死性白化缺失复合体。 这些似乎 包括专门与控制相关的调节基因 肝细胞分化。 遗传学、发育学方法 生物学、生物化学、体细胞遗传学、电子显微镜、 细胞学和分子生物学为这些研究服务。 研究 这里提出的为出生研究提供了模型系统 人类新陈代谢的缺陷和先天性错误。 它打开了 对先天性畸形病因学的新看法 强调具有相似条件的遗传异质性 外观，例如糖原贮积病和其他代谢性疾病 异常。