VISUAL OCULOMOTOR INTEGRATION IN STRIATUM

纹状体的视觉动眼整合

基本信息

批准号：
2159549
负责人：
BRUCE V UPDYKE
金额：
$ 9.49万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-04-01 至 1994-11-30
项目状态：
已结题

项目摘要

The focus of the proposed studies is upon analyzing the anatomical substrates of visual and oculomotor processing in striatum. Striatum is strongly implicated in visuomotor integration by evidence that it participates in sequencing complex volitional behaviors, and by specific evidence showing (i) extensive and specific interconnections with visual and oculomotor areas, (ii) striatal and nigral cells may discharge selectively preceding purposive saccades, and (iii) eye movement disorders are characteristic of basal ganglia disease. The striatum also exhibits a complex intrinsic organization consisting of a lattice-like arrangement of histochemically specific compartments which appear to form both the basis for integration within striatum and for segregation of its input-output connections. The proposed studies will employ direct electrophysiological mapping for visual representation, and intracranial microstimulation mapping for eye movement representation, combined with immunohistochemical methods to demonstrate striatal compartments, and anterograde and retrograde tracer methods to demonstrate striatal connections. The following specific aims will be addressed: (1) Determine how electrophysiologically defined representations of visual space are related to the immunohistochemical compartments of striatum; (2) Determine how representations of eye movement are related to immunohistochemically defined striatal compartments; (3) Determine whether interdigitation or overlap occurs between contiguous functionally defined visual and eye movement compartments in striatum: (4) Determine how the segregated output pathways which arise within striatum are related to specific electrophysiologically defined compartments and to immunohistochemically defined compartments. Successful execution of the specific aims of the project will shed new light on the specific contributions of striatum to oculomotor control, upon the details of neuronal circuitry which link visual areas with oculomotor structures via striatum, and upon the fundamental principles by which brain employs visual information for initiation and guidance of voluntary movement. The long term health related consequences of this work is expected to be an improvement in the methods for diagnosis and treatment of debilitating oculomotor disorders and visuomotor apraxias.

拟议研究的重点是分析解剖学纹状体中的视觉和眼动物处理的底物。纹状体是通过证据表明它参与测序复杂的自愿行为，并通过特定的证据显示（i）与视觉的广泛而特定的互连和眼动物区域，（ii）纹状体和ni骨细胞可能放电有选择性的目的扫视和（iii）眼动障碍是基底神经节病的特征。纹状体也表现出复杂的内在组织，由晶格式布置组成在组织化学上特定的隔室，似乎形成了两个基础用于在纹状体内的集成和其输入输出的分离连接。拟议的研究将采用直接的电生理映射进行视觉表示和颅内微刺激映射的眼睛运动表示，结合免疫组织化学方法展示纹状体室，同类和逆行示踪剂证明纹状体连接的方法。以下特定目标将被解决：（1）确定电生理学的定义视觉空间的表示与免疫组织化学有关纹状体的室；（2）确定眼睛的表示运动与免疫组织化学定义的纹状体有关车厢；（3）确定是否发生互插还是重叠在连续定义的视觉和眼睛运动之间纹状体中的隔室：（4）确定隔离输出途径的方式纹状体内发生的与特定的电生理有关定义的隔室和免疫组织化学的隔室。成功执行该项目的具体目标将使新的新关于纹状体对眼球控制的特定贡献的光明，在神经元电路的细节上，将视觉区域与通过纹状体以及基于基本原理的眼动物结构大脑采用视觉信息进行启动和指导自愿运动。长期与健康有关的后果预计工作将是诊断方法的改善治疗令人衰弱的动眼疾病和视觉运动失败。