VISUAL OCULOMOTOR INTEGRATION IN STRIATUM

纹状体的视觉动眼整合

• 批准号: 3261117
• 负责人: BRUCE V UPDYKE
• 金额: $ 5.22万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3261117
• 关键词: Macaca; afferent nerve; brain disorders; cats; caudate nucleus; efferent nerve; electrophysiology; evoked potentials; eye movement disorders; eye movements; histology; lenticular nucleus; neural information processing; neuroanatomy; oculomotor nuclei; substantia nigra; thalamus; visual cortex; visual pathways

The project will analyze the anatomical substrates of oculomotor integration related to the neostriatum (caudate nucleus specifically). Caudate nucleus is strongly implicated in eye movement control by virtue of (i) afferent and efferent connections with many CNS regions of identified oculomotor function, (ii) specific eye movement disorders associated with basal ganglia disease, and (iii) experimental observations directly linking the strio-nigral and nigro-tectal pathways with higher order contingencies of eye movement control. The first aim of the project is to analyze the organization of striatum with respect to the distributions of corticostriate projections originating from identified visuomotor cortical areas. This will involve (i) determining whether caudate contains specific foci of convergence of visuomotor corticostriate projections, (ii) mapping the distribution of these foci, and (iii) determining the degree of overlap within caudate of multiple converging visuomotor cortical inputs. This aim will be addressed by mapping focal evoked potentials elicited by direct electrical stimulation of cortical visuomotor areas to identify the distribution of corticostriatal projections and their co-distributions considered 2 and 3 at a time. The second aim is to study the connections of the identified striatal foci in order to analyze their overall patterns of connectivity with other identified oculomotor regions. Caudate foci identified as receiving converging visuomotor cortical inputs will be injected with 3H-amino acid and with WGA conjugated HRP to study the pattern of their efferent and afferent connections. Analysis of these anatomical connections will permit detailed descriptions of important, and largely unexplored, anatomical substrates of the higher order eye movement control subsystems. The long term objective of this approach is to employ the basic anatomical "wiring diagram" to develop a predictive model of cortical and striatal contribution to oculomotor control. It is expected that this approach will eventually (i) shed new light on the role of higher centers in oculomotor control, (ii) predict new underlying principles of control which will be amenable to direct experimental tests, and (iii) explain some underlying mechanisms of clinical oculomotor syndromes related to cortical damage, basal ganglia disease, and congenital apraxias. The long term consequences of such an approach should be an improvement in methods of diagnosis and treatment of many debilitating oculomotor disorders.

该项目将分析动眼的解剖基板 与新纹状体相关的整合（特别是尾状核）。 尾状核强烈与眼动控制有关 （i）与已确定的许多中枢神经系统区域的传入和传出连接 眼动函数，（ii）与 基底神经节病，（iii）实验观察直接连接 具有高阶偶然性的横纹核和尼格罗型直肠途径 眼动控制。 该项目的第一个目的是分析 纹状体的组织 源自确定的视觉运动皮质的皮质隔膜预测 区域。 这将涉及（i）确定尾状的是否包含特定 Visuomotor Corticosticostiate投影的收敛焦点，（ii）映射 这些焦点的分布以及（iii）确定重叠程度 在多个收敛的视觉运动皮质输入的尾声中。 这个目标 将通过映射直接引起的焦点诱发电位来解决 皮质视觉运动区域的电刺激以识别 皮层预测及其共同分布的分布 一次考虑2和3。 第二个目的是研究联系 确定的纹状体灶，以分析其整体模式 与其他已确定的眼动区的连通性。 尾状焦点 被确定为接收融合的视觉运动皮质输入将是 注射3H-氨基酸和WGA共轭HRP来研究 它们的传出和传入连接的模式。 这些分析 解剖联系将允许对重要的详细描述，并且 高阶眼运动的大部分未开发的解剖基质 控制子系统。 这种方法的长期目标是采用 基本的解剖学“接线图”，以开发一个预测模型 皮质和纹状体对动眼控制的贡献。 预计 这种方法最终将（i）解散了更高的作用 眼球控制中心，（ii）预测 控制可以正常进行实验测试，并且（iii） 解释一些与临床眼球综合征相关的潜在机制 为了皮质损伤，基底神经节病和先天性失毒。 这 这种方法的长期后果应该是改善 诊断和治疗许多使动眼运动的方法 疾病。