Vestibulo-Cerebellar Circuits

前庭小脑回路

基本信息

批准号：
7228434
负责人：
Carey David Balaban
金额：
$ 30.06万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-03-01 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7228434
关键词：
Acceleration Afferent Pathways Amygdaloid structure Animals Anterior Anxiety Anxiety Disorders Axon Brain Stem Cell Nucleus Cells Characteristics Class Condition Dimensions Disease Elevation Equilibrium Grant HTR2A gene Head Hippocampus (Brain)Hypothalamic structure Investigation Lateral Link Lobe Macaca Maps Medial Mediating Methods Monkeys Movement Neurons Nuclear Pathway interactions Pattern Physiological Physiology Population Positioning Attribute Prefrontal Cortex Primates Progress Reports Property Prosencephalon Rattus Rotation Semicircular canal structure Serotonin Receptor 5-HT2C Signal Transduction Site Spinal Cord Stimulus Structure Testing Tracer Trapezoid bone structure United States National Aeronautics and Space Administration Vestibular nucleus structure Yaws base cranial vestibular nucleus structure design dorsal raphe nucleus immunoreactivity medial vestibular nucleus nerve supply noradrenergic otoconia parabrachial nucleus raphe nuclei research study response serotonin receptor

项目摘要

DESCRIPTION (provided by applicant): The proposed neuroanatomical and electrophysiological studies continue investigations of the organization of pathways that mediate vestibular influences on autonomic and limbic pathways, particularly in pathways that mediate the linkage between balance disorders and anxiety disorders. Three circuitry networks appear to be critical for balance-anxiety link: a vestibulo-parabrachial nucleus (PBN) network, coeruleo-vestibular (noraderenergic) network and raphe-vestibular (serotonergic and non-serotonergic) networks. The physiology and connections of the PBN network will be studied in primates; the organization of the noradrenergic and raphe pathways will be explored in rats. Our on-going primate studies have shown that a caudal region of PBN contains neurons that receive vestibular nuclear input and are sensitive to whole body rotation. New electrophysiologic studies in alert primates are directed at elucidating the spatial organization of responses of parabrachial nucleus neurons during whole body rotation. Two main foci will be characterization of otolith-related responses and a test of the hypothesis that responses will differ for predictable and unpredictable whole body rotation in three dimensions. Anatomical studies in primates are also designed elucidate the afferent and efferent connections of this vestibulo-recipient region of PBN. Our on-going studies have shown that the dorsal raphe nucleus, nucleus raphe obscurus and nucleus raphe pallidus provide serotonergic input to the vestibular nuclei. Anatomical studies will elucidate the topography of these projections, the distribution of immunoreactive serotonin receptors in the vestibular nuclei and test specific hypotheses regarding the organization of collateralized raphe projections to the vestibular nuclei and other sites. Finally, anatomical studies in rats will test specific hypotheses regarding the organization of collateralized noradrenergic projections to the vestibular nuclei and other sites.

描述（由申请人提供）：拟议的神经解剖学和电生理研究继续研究介导前庭影响对自主神经和边缘途径的途径的组织，尤其是在介导平衡障碍和焦虑症之间联系的途径。三个电路网络似乎对于平衡焦虑链接至关重要：前庭 - 寄生虫核（PBN）网络，凝血率 - 视网膜（Noraderenenagic）网络和Raphe-vestibular（血清旁通和非塞罗托尼能）网络。 PBN网络的生理和联系将在灵长类动物中进行研究；在老鼠中将探索去甲肾上腺素和兰斯途径的组织。我们正在进行的灵长类动物研究表明，PBN的尾部区域包含接受前庭核输入的神经元，对全身旋转敏感。警报灵长类动物中的新的电生理研究旨在阐明整个体内旋转过程中甲状管核神经元反应的空间组织。两个主要焦点将是耳石相关反应的表征，以及对响应在三个维度上可预测且不可预测的全身旋转的假设的检验。设计中的解剖学研究还阐明了PBN的这一前庭 - 恢复区域的传入和传出连接。我们正在进行的研究表明，背部核核，核Raphe obscurus和raphe pallidus核核为前庭核提供了血清素能输入。解剖学研究将阐明这些投影的地形，前庭核中免疫反应性5-羟色胺受体的分布，并检验有关将侧支raphe投影组织到前庭核和其他部位的特定假设。最后，大鼠的解剖学研究将检验有关对前庭核和其他部位的抵押甲肾上腺素能预测组织的特定假设。