NOVEL VACCINE TARGET ANTIGENS IN HIV-1 INFECTED CELLS

HIV-1感染细胞中的新型疫苗靶标抗原

• 批准号: 2873769
• 负责人: MAURICE ZAUDERER
• 金额: $ 23.47万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2873769
• 关键词: AIDS vaccines; HIV infections; active immunization; antigens; cell line; cellular immunity; clinical research; complementary DNA; cytotoxic T lymphocyte; gene expression; genetically modified animals; human genetic material tag; human immunodeficiency virus 1; human subject; human tissue; immunogenetics; laboratory mouse; monocyte; recombinant virus; subtraction hybridization; vaccine development; vaccinia virus; vector vaccine

It is proposed to identify host genes whose expression is deregulated as a results of HIV-1 infection. Characterization of altered host gene expression in HIV-1 infected cells could lead to important insights into the physiology of infection.

建议鉴定其表达因以下原因而失调的宿主基因： HIV-1 感染。 HIV-1感染细胞中宿主基因表达改变的表征 可能会对感染的生理学产生重要的见解。