Chemical study of insect-plant interactions: a contribution to biorational control of crop pests

昆虫与植物相互作用的化学研究：对作物害虫生物合理控制的贡献

• 批准号: BB/R022755/1
• 负责人: Toby Bruce
• 金额: $ 10万
• 依托单位: Keele University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR022755%2F1
• 关键词: Chemical; study; insect; plant; interactions

New solutions for managing insect pests are urgently needed due to evolution of resistance to current insecticides. This project focuses on development and bioactivity testing of novel nanotech formulations of plant secondary metabolites that could provide new options for crop protection. The Federal University of São Carlos (UFSCar) group has strong preliminary data showing that nanotech formulations of certain plant flavonoids complexed with Mg (II) substantially reduce growth of insects. Preliminary experiments done by the Keele University (KU) group with PAA (poly(allylamine)) nanotech formulations of essential oils have shown highly significant repellent action, with greatly enhanced activity compared to conventionally formulated material. UK-Brazil collaboration would provide an ideal opportunity to strengthen this new and promising area of research. The project includes Workshops and exchange visits to build a research network between the groups. Both groups will share expertise and work together to create novel nanotech formulations of plant secondary metabolites (flavonoids such as Hesperidin and Naringenin, phenolic acids and essential oils). Parallel experiments will be conducted testing activity against selected insects, chosen due to their relevance to Brazilian agriculture and insecticide resistance challenges. Bioassays with Western flower thrips, Frankliniella occidentalis, and peach-potato aphid, Myzus persicae, will be conducted at KU; with whitefly, Bemisia tabaci, at São Paulo State University (UNESP), and with fall armyworm, Spodoptera frugiperda at UFSCar. Antibiotic, antifeedant and repellent activity will be tested for using established methods. The experiments conducted in the pump-priming project will reveal the potential for use of nanotechnology to improve the formulation of plant secondary metabolites for use against insects. The project will benefit from the expertise in the KU School of Pharmacy Co-I who has considerable expertise in development of nanotech formulations for the medical sector. We will consider the extent to which low cost technologies already developed for medicines can be translated into the agricultural field. In addition to the programme of empirical research, we will also conduct a literature review of the area and submit this to a high quality scientific journal as a contribution to knowledge. We think there is considerable potential for cross-fertilisation between the disciplines involved in the project (chemistry, medicine and entomology). This has potential to allow agricultural formulation technology to "leapfrog" into nanotechnology by using approaches already developed for Medicine. Furthermore, there will, of course, be insights gained by sharing insights with the Brazilian scientists who are at the forefront of the development of nanotechnology for crop protection. The project has considerable potential to generate much needed new tools for managing insect pests of crops.The project will allow us to test the hypothesis that bioactivity of plant secondary metabolites can be enhanced by delivery via novel nanotech formulations.

由于对现有杀虫剂的抗药性的进化，迫切需要针对害虫的新解决方案。该项目重点开发和测试植物次生代谢物的新型纳米技术配方，这可以为作物保护提供新的选择。 ) 小组拥有强有力的初步数据表明，某些植物类黄酮与 Mg (II) 复合的纳米技术配方可显着减少昆虫的生长，基尔大学 (KU) 小组与 PAA 进行的初步实验。 （聚（烯丙胺））精油纳米技术配方已显示出非常显着的驱虫作用，与精心配制的材料相比，其活性大大增强，这将为加强这一新的、有前景的研究领域提供理想的机会。该项目包括研讨会和交流访问，以在两个小组之间建立研究网络，并共同开发植物次生代谢物（橙皮苷和柚皮素等黄酮类化合物、酚酸和甘油三酯）的新型纳米技术配方。将针对选定的昆虫进行平行实验，这些昆虫的选择是因为它们与巴西农业和杀虫剂抗性挑战相关，将在堪萨斯大学对粉虱进行生物测定，其中包括西方花条、桃蚜和桃蚜；烟粉虱 (Bemisia tabaci)，位于圣保罗州立大学 (UNESP)，以及草地贪夜蛾 (Spodoptera frugiperda)，位于圣保罗州立大学 (UNESP) UFSCar. 将使用既定方法测试抗生素、拒食和驱虫活性。在泵启动项目中进行的实验将揭示利用纳米技术改进植物次生代谢物配方以对抗昆虫的潜力。来自 KU 药学院 Co-I 的专业知识，他们在医疗领域纳米技术配方的开发方面拥有丰富的专业知识。此外，我们还将考虑将已经开发的低成本药物技术转化到农业领域的程度。对于实证研究计划，我们还将对该领域进行文献综述，并将其提交给高质量的科学期刊，作为对知识的贡献。我们认为该项目所涉及的学科之间存在巨大的交叉发展潜力（通过使用已经为医学开发的方法，这有可能使农业配方技术“跨越”到纳米技术此外，当然，通过与巴西科学家分享见解也可以获得见解。走在发展的最前沿该项目具有巨大的潜力，可以为作物害虫产生急需的新工具，该项目将使我们能够检验通过新型纳米技术制剂可以增强植物次生代谢物的生物活性的假设。

项目成果

Characterization of Nanospheres Containing Zanthoxylum riedelianum Fruit Essential Oil and Their Insecticidal and Deterrent Activities against Bemisia tabaci (Hemiptera: Aleyrodidae).

• DOI: 10.3390/molecules23082052
• 发表时间: 2018-08-16
• 期刊: Molecules (Basel, Switzerland)
• 作者: Pereira KC;Quintela ED;da Silva DJ;do Nascimento VA;da Rocha DVM;Silva JFAE;Forim MR;Silva FG;Cazal CM
• 通讯作者: Cazal CM

Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-As

柑橘渣中橙皮苷的增值：微波 As 的评价

• DOI: 10.21577/0103-5053.20220050
• 发表时间: 2022
• 期刊: Journal of the Brazilian Chemical Society
• 影响因子: 1.4
• 作者: Da Silva D