Chemical study of insect-plant interactions: a contribution to biorational control of crop pests

昆虫与植物相互作用的化学研究：对作物害虫生物合理控制的贡献

• 批准号: BB/R022755/1
• 负责人: Toby Bruce
• 金额: $ 10万
• 依托单位: Keele University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR022755%2F1
• 关键词: Chemical; study; insect; plant; interactions

New solutions for managing insect pests are urgently needed due to evolution of resistance to current insecticides. This project focuses on development and bioactivity testing of novel nanotech formulations of plant secondary metabolites that could provide new options for crop protection. The Federal University of São Carlos (UFSCar) group has strong preliminary data showing that nanotech formulations of certain plant flavonoids complexed with Mg (II) substantially reduce growth of insects. Preliminary experiments done by the Keele University (KU) group with PAA (poly(allylamine)) nanotech formulations of essential oils have shown highly significant repellent action, with greatly enhanced activity compared to conventionally formulated material. UK-Brazil collaboration would provide an ideal opportunity to strengthen this new and promising area of research. The project includes Workshops and exchange visits to build a research network between the groups. Both groups will share expertise and work together to create novel nanotech formulations of plant secondary metabolites (flavonoids such as Hesperidin and Naringenin, phenolic acids and essential oils). Parallel experiments will be conducted testing activity against selected insects, chosen due to their relevance to Brazilian agriculture and insecticide resistance challenges. Bioassays with Western flower thrips, Frankliniella occidentalis, and peach-potato aphid, Myzus persicae, will be conducted at KU; with whitefly, Bemisia tabaci, at São Paulo State University (UNESP), and with fall armyworm, Spodoptera frugiperda at UFSCar. Antibiotic, antifeedant and repellent activity will be tested for using established methods. The experiments conducted in the pump-priming project will reveal the potential for use of nanotechnology to improve the formulation of plant secondary metabolites for use against insects. The project will benefit from the expertise in the KU School of Pharmacy Co-I who has considerable expertise in development of nanotech formulations for the medical sector. We will consider the extent to which low cost technologies already developed for medicines can be translated into the agricultural field. In addition to the programme of empirical research, we will also conduct a literature review of the area and submit this to a high quality scientific journal as a contribution to knowledge. We think there is considerable potential for cross-fertilisation between the disciplines involved in the project (chemistry, medicine and entomology). This has potential to allow agricultural formulation technology to "leapfrog" into nanotechnology by using approaches already developed for Medicine. Furthermore, there will, of course, be insights gained by sharing insights with the Brazilian scientists who are at the forefront of the development of nanotechnology for crop protection. The project has considerable potential to generate much needed new tools for managing insect pests of crops.The project will allow us to test the hypothesis that bioactivity of plant secondary metabolites can be enhanced by delivery via novel nanotech formulations.

由于对当前杀虫剂的抗性，急需急需管理害虫的新解决方案。该项目着重于植物二级代谢物的新型纳米技术公式的开发和生物活性测试，这些配方可以为作物保护提供新的选择。圣卡洛斯联邦大学（UFSCAR）组具有强大的初步数据，表明某些与MG（II）复合的某些植物类黄酮的纳米技术大大减少了昆虫的生长。 Keele大学（KU）组具有PAA（Poly（Allylamine））精油的纳米技术的初步实验表现出了非常明显的复制作用，与​​常规配制的材料相比，活动具有很大的增强活性。英国 - 巴西的合作将为加强这一新的和有望的研究领域提供理想的机会。该项目包括研讨会和交换访问，以在小组之间建立研究网络。两组将共享专业知识并共同创建植物二级代谢产物的新型纳米技术公式（黄酮类药物，例如硫糖蛋白和纳林宁，酚酸和精油）。平行实验将进行针对选定昆虫的测试活性，因为它们与巴西农业和杀虫剂耐药性挑战有关。西方花蓟马，西方富兰克利亚氏芽和桃花蚜虫Myzus persicae的生物测定将在KU进行；与粉丝，圣保罗州立大学（UNESP）的Bemisia Tabaci，以及Ufscar的Spodoptera Frugiperda的秋天虫。将测试使用既定方法，将测试抗生素，抗虫和驱虫活性。在泵送项目中进行的实验将揭示使用纳米技术来改善植物二级代谢物的公式，以抗昆虫。项目将受益于KU药学院Co-I学院的专业知识，该学院在医疗领域的纳米技术公式开发方面具有丰富的专业知识。我们将考虑可以将已经开发的药物开发的低成本技术转化为农业领域的程度。除了实证研究计划外，我们还将对该领域进行文献综述，并将其提交高质量的科学杂志，以贡献知识。我们认为，该项目涉及的学科（化学，医学和昆虫学）之间具有巨大的交叉灌输潜力。这有可能使农业公式技术通过使用已经开发的医学方法将农业技术“跨越”纳米技术。此外，当然，通过与巴西科学家分享洞察力的见解，这将获得洞察力，这些科学家处于纳米技术的发展方面的最前沿，以进行作物保护。该项目具有产生急需的新工具来管理农作物的虫害的潜力。该项目将使我们能够通过新颖的纳米技术配方来测试植物二级代谢物的生物活性的假设。

项目成果

Characterization of Nanospheres Containing Zanthoxylum riedelianum Fruit Essential Oil and Their Insecticidal and Deterrent Activities against Bemisia tabaci (Hemiptera: Aleyrodidae).

• DOI: 10.3390/molecules23082052
• 发表时间: 2018-08-16
• 期刊: Molecules (Basel, Switzerland)
• 作者: Pereira KC;Quintela ED;da Silva DJ;do Nascimento VA;da Rocha DVM;Silva JFAE;Forim MR;Silva FG;Cazal CM
• 通讯作者: Cazal CM

Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-As

柑橘渣中橙皮苷的增值：微波 As 的评价

• DOI: 10.21577/0103-5053.20220050
• 发表时间: 2022
• 期刊: Journal of the Brazilian Chemical Society
• 影响因子: 1.4
• 作者: Da Silva D