EFFECT OF IV INFUSIONS ON ENERGY BALANCE

静脉输液对能量平衡的影响

基本信息

批准号：
3240348
负责人：
HENRY S KOOPMANS
金额：
$ 2.85万
依托单位：
UNIVERSITY OF CALGARY
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-05-01 至 1991-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3240348
关键词：
aminoacid bioperiodicity eating fats gastrointestinal hormones gastrointestinal transplantation glucose hormone regulation /control mechanism intravenous administration laboratory rat metabolism neuroendocrine system nutrition related tag obesity weight control

项目摘要

The main objective of the proposed research is to determine which internal signals are involved in the control of daily food intake and energy expenditure. The long-term objective is to understand the internal control of energy balance well enough to develop a medical treatment for obesity. Obesity is a risk factor for several debilitating diseases, including diabetes, hypertension, stroke and heart disease. A medical treatment for obesity would greatly reduce human suffering and would decrease the societal cost of health care. The first specific aim is to assess the effect of intravenous infusions of glucose and amino acids and of medical fat emulsions on voluntary food intake and metabolic rate. Pilot studies have shown that the rats respond to these nutrients in very different ways: they reduce their food intake following glucose infusions but not following fat infusions. The second aim is to determine whether the effect of glucose infusions are different during the night when neural and hormonal signals from the digestive tract are present or during the day when these signals are absent. The third specific aim is to determine whether the failure of the rats to respond to intravenous fats was due to the non-physiological form of the infused fats. The fourth aim is to investigate the relative importance of blood metabolites, intestinal hormones and intestinal nerves in the control of energy balance. This will be done by transplanting a supernumerary intestine into the peritoneal cavity of another rat and infusing fat into either the rat's natural intestine, into the denervated transplant or into the bloodstream. The final specific aim is to infuse promising gut peptides directly into the bloodstream in such a way as to mimic the normal blood levels of the hormones after a meal. Analogs of the hormones may provide a medical treatment for obesity.

拟议研究的主要目的是确定哪些内部信号涉及每日食物的控制进气和能量消耗。长期目标是了解能量平衡的内部控制足以开发肥胖症的医疗。肥胖是危险因素对于几种使人衰弱的疾病，包括糖尿病，高血压，中风和心脏病。肥胖症的医疗大大减少人类的痛苦，并减少社会医疗保健费用。第一个具体目的是评估效果葡萄糖和氨基酸的静脉注射以及医疗自愿摄入和代谢率的脂肪乳液。飞行员研究表明，大鼠在非常对这些营养的反应不同的方式：它们减少葡萄糖后的食物摄入量输注但不遵循脂肪输注。第二个目标是确定葡萄糖输注的作用是否不同在夜晚的神经和激素信号消化道存在或在这些信号的白天不存在。第三个具体目的是确定是否大鼠无法应对静脉脂肪是由于注入脂肪的非生理形式。第四个目标是研究血液代谢物的相对重要性，能量控制中的肠激素和肠道神经平衡。这将通过移植超级人物来完成肠道进入另一只大鼠的腹膜腔并注入脂肪进入大鼠的天然肠道，进入被剥夺的移植或进入血液。最终的具体目的是将有希望的肠肽直接注入到血液中一种模仿激素的正常血液水平的方式饭后。激素的类似物可以提供医学治疗肥胖症。