Studying the Biology and Behavior of Autism at 1-Year: The Well-Baby Check-Up App

研究自闭症一岁的生物学和行为：健康婴儿检查应用程序

基本信息

批准号：
8196830
负责人：
Karen L Pierce
金额：
$ 27.22万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-12-17 至 2012-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8196830
关键词：
1 year old 2 year old Address Age Age-Months Anti-Inflammatory Agents Anti-inflammatory Area Authorization documentation Autistic Disorder Back Behavior Behavioral Biological Biological Assay Biology Bioperiodicity Birth Budgets Castes Characteristics Child Child Development Childhood Clinical Clinical Pathology Cognitive Communication Data Data Analyses Daughter Development Developmental Delay Disorders Diagnosis Diagnostic Disclosure Disease Early identification Eating Equilibrium Ethics Exhibits Eye Functional Imaging Functional Magnetic Resonance Imaging Funding Gastroenteritis Gifts Goals Grant Growth Factor Head circumference Human Resources Immune Infant Inflammatory Irritable Bowel Syndrome Judgment Laboratories Language Life Literature Measures Medical Medical Records Medical Staff Methods Modeling Mothers Normal Range Outcome Paper Parents Pattern Performance Phase Plasma Pregnancy Principal Investigator Procedures Process Prospective Studies Psychometrics Publications Published Comment Questionnaires ROC Curve Recruitment Activity Reliance Research Research Personnel Resources Risk Role Sampling Sampling Biases Sampling Studies Schools Screening procedure Siblings Sleep Son Staging Stress Symptoms TNF gene Test Result Testing Time Toddler Translating Visit Work autism spectrum disorder brain size brief screening checkup examination chemokine cost cytokine design deviant early childhood experience falls follow-up gaze high risk high risk infant human subject improved indexing instrument interest joint attention neuroinflammation novel strategies offspring pediatrician pre-clinical preference programs prospective response social social communication standardize measure success suspected autism tool volunteer

项目摘要

DESCRIPTION (provided by applicant): There is a paucity of behavioral data and an absence of biological data on autism at 12 months of age. The reason for these major gaps in vital information is because autism remains behaviorally, not biologically, defined and diagnosed. Prospective, hypothesis- driven studies of behavior and biology in autistic infants would be powerful and are essential, but are missing. Currently, the infant sibling design is the only prospective approach in use. This design is strong but also has limitations including high costs, long-time scale, potential for sampling bias, and the heavy demands on the researcher to identify, recruit, and maintain contact long-term with large numbers of mothers and infants. We propose a different prospective strategy, called the "1-Year Well Baby Check-Up Approach", that does not involve any of these limitations. Because most babies see their pediatrician at 1 year, we propose to have 60 pediatricians give a brief screening questionnaire to parents while in the waiting room, the CSBS-DP Infant Toddler Checklist (Wetherby and Prizant, 2002), at every 1-year well baby check-up. Infants whose scores fall outside of the normal range will be referred to us for follow-up diagnostic and psychometric testing. Babies judged to be at-risk for autism or developmental delay (DD) will be followed longitudinally to determine the success rate of this procedure. Control subjects will be babies who score within the normal range on the checklist. Success of this model approach can have an immediate impact on pediatric practice. Babies judged to be at-risk for autism or DD, as well as controls, will participate in two studies aimed at demonstrating that important behavioral and biological information can be obtained via this approach. In one study, to address the important question of immunological abnormality in autism early in life, we will use state- of-the-art methods to assay plasma levels of specific immune significant cytokines and growth factors. In the second study, to address important questions about early social interest and orienting abnormalities in autism, we will use a quantitative experimental procedure for investigating social preference behavior and eye gaze patterns. Successful identification of biological and behavioral features of autism at 12 months of age will have a major impact by introducing the possibility of pediatric referral of high risk infants for quantitative and objective tests that can aid in earlier diagnostic and treatment decisions.7.

描述（由申请人提供）：行为数据很少，并且缺少12个月大时自闭症的生物学数据。这些重要信息中这些主要差距的原因是因为自闭症在行为，不是生物学上，定义和诊断上。自闭症婴儿中对行为和生物学的前瞻性，假设驱动的研究将是强大的，并且是必不可少的，但缺失。目前，婴儿同胞设计是唯一使用的潜在方法。这种设计很强大，但也有局限性，包括高成本，长期规模，抽样偏见的潜力以及对研究人员对识别，招募和维持与大量母亲和婴儿的长期接触的巨大要求。我们提出了一种不同的前瞻性策略，称为“一年井的婴儿检查方法”，这不涉及这些限制。因为大多数婴儿在1年就见到他们的儿科医生，所以我们建议有60位儿科医生对父母进行简短的筛查问卷，同时在候诊室，CSBS-DP婴儿幼儿清单（Wetherby and Prizant，2002年），每1年的婴儿检查。分数超出正常范围的婴儿将被转交给我们进行后续诊断和心理测试。被认为是自闭症或发育迟缓（DD）的婴儿将纵向遵循以确定此程序的成功率。控制对象将是在清单上正常范围内得分的婴儿。这种模型方法的成功可能会对小儿实践产生直接影响。判断为自闭症或DD危险的婴儿以及对照组将参与两项研究，旨在证明可以通过这种方法获得重要的行为和生物学信息。在一项研究中，为了解决生命早期自闭症免疫学异常的重要问题，我们将使用状态方法来分析特定免疫明显细胞因子和生长因子的血浆水平。在第二项研究中，为了解决有关自闭症早期社会兴趣和定向异常的重要问题，我们将使用定量的实验程序来研究社会偏好行为和眼睛凝视模式。在12个月大时，成功鉴定自闭症的生物学和行为特征将通过引入小儿转诊高风险婴儿进行定量和客观测试的可能性，从而产生重大影响。