BLOOD GLUCOSE-HEMOGLOBIN A1C & DIABETIC VASCULAR DISEASE

血糖-血红蛋白 A1C

基本信息

批准号：
3238700
负责人：
KENNETH H GABBAY
金额：
$ 48.42万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-08-01 至 1993-07-31
项目状态：
已结题

项目摘要

The Diabetes Control and Vascular Disease study seeks to determine the natural history of juvenile diabetes and the relation of diabetic glycemia and other determinants to the development of microvascular and macrovascular disease in a large homogeneous group of Type I diabetic patients. It is proposed to continue observations of this well-defined cohort to further characterize occurrences of diabetic complications in relation to their determinants. Our aims are to: 1) delineate and define the evolution of small vessel disease in the retina of these young- adult diabetics by serial ophthalmological examinations (clinical, fluorescein angiography, fundus photography, retinal blood flow measurement by the laser Doppler technique), 2) further refine our recently developed index of the rate of progression of early diabetic retinopathy and develop other empirical methods for hierarchical scoring of other phases of diabetic retinopathy, 3) relate the severity thus measured and its components to the characteristics of the patient and the disease (e.g. level of glycemia, muscle CBMT, hormonal, genetic factors), 4) explore the role of the genome in susceptibility to diabetes and its complications by examining, separately and jointly, the relation of extended major histocompatibility (MHC) haplotypes (chr. 6), haplotypes defined by restriction fragment length polymorphisms (RFLPs) of large DNA regions on the short arm of chr. 11, and RFLPs for human IGF-I, IGF-II and aldehyde reductases, and 5) complete the typing and establishment of permanent lymphoblastoid cell lines from every study participant and selected families.

糖尿病控制和血管疾病研究旨在确定青少年糖尿病的自然历史和关系糖尿病性血糖和其他决定因素大型同质性的微血管和大血管疾病 I型糖尿病患者。建议继续观察这个定义明确的队列以进一步表征糖尿病并发症的发生决定因素。我们的目标是：1）描述并定义这些年轻的视网膜中小血管疾病的演变成人糖尿病患者通过连续眼科检查（临床，荧光素血管造影，眼底摄影，视网膜血流通过激光多普勒技术测量），2）进一步完善我们的最近开发了早期进展率的指数糖尿病性视网膜病并开发其他经验方法糖尿病性视网膜病的其他阶段的分层评分，3）将因此测量的严重程度及其组成与患者和疾病的特征（例如血糖，肌肉CBMT，荷尔蒙，遗传因素），4）探索基因组在糖尿病及其易感性中的作用通过分别和共同检查并发症扩展的主要组织相容性（MHC）单倍型（Chr。6），由限制片段长度多态性定义的单倍型 Chr短臂上的大型DNA区域的（rflps）。 11和RFLP 对于人IGF-I，IGF-II和醛还原酶，以及5）永久淋巴母细胞系的打字和建立来自每个研究参与者和选定家庭。