Targeted Drug Delivery to the Cornea of the Eye Via Thin-Film Slow Release Technology.

通过薄膜缓释技术将靶向药物输送至眼角膜。

基本信息

批准号：
BB/N022106/1
负责人：
Andrew Quantock
金额：
$ 14.15万
依托单位：
CARDIFF UNIVERSITY
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FN022106%2F1
关键词：
Targeted Drug Delivery Cornea Eye

项目摘要

Getting a drug to where it is needed is essential if it is to be efficient. Some drugs are effective when injected into the bloodstream or taken as tablets. For the cornea at the front of the eye, drugs can also be applied as eye drops. The problem with this, however, is that eye drops flow away from the cornea and end up under the eyelid or in the nasal passage. Thus, the drug in the eye drop is not active where it is needed. To overcome this problem we will bind drugs to thin films, which will be a bit like contact lenses. But the binding of the drug will not be tight. This means that when the film is worn like a contact lens the drug is steadily released into the cornea, exactly where it is needed. A special type of drug called a ROCK inhibitor can help damaged cells in the cornea recover. And because of this we will use a ROCK inhibitor as the drug in our new contact lens-type films, to establish how it is released into the cornea in a more targeted manner than with eye drops.

如果要高效，将药物送入需要的地方至关重要。一些药物在注入血液或作为片剂时有效。对于眼前的角膜，也可以在眼滴时使用药物。然而，问题在于，眼睛滴从角膜上流出，最终在眼睑或鼻腔通道下方流动。因此，在需要的地方，眼滴中的药物不活跃。为了克服这个问题，我们将将药物与薄膜结合，这有点像隐形眼镜。但是该药物的结合不会很紧。这意味着，当胶片像隐形眼镜一样佩戴时，药物会稳步释放到角膜中，正是在需要的地方。一种称为岩石抑制剂的特殊类型的药物可以帮助角膜恢复中受损的细胞。因此，我们将使用岩石抑制剂作为我们的新隐形眼镜型膜中的药物，以确定与眼滴相比，如何以更有针对性的方式将其释放到角膜中。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Microwave treatment of the cornea leads to localised disruption of the extracellular matrix.

DOI：
10.1038/s41598-018-32110-0
发表时间：
2018-09-13
期刊：
Scientific reports
影响因子：
4.6
作者：
Morgan SR;Hieda O;Nakai Y;Boote C;Hayes S;Kinoshita S;Meek KM;Quantock AJ
通讯作者：
Quantock AJ

A Surgical Cryoprobe for Targeted Transcorneal Freezing and Endothelial Cell Removal.

DOI：
10.1155/2017/5614089
发表时间：
2017
期刊：
Journal of ophthalmology
影响因子：
1.9
作者：
Akhbanbetova A;Nakano S;Littlechild SL;Young RD;Zvirgzdina M;Fullwood NJ;Weston I;Weston P;Kinoshita S;Okumura N;Koizumi N;Quantock AJ
通讯作者：
Quantock AJ

A Composite System Based upon Hydroxypropyl Cyclodextrins and Soft Hydrogel Contact Lenses for the Delivery of Therapeutic Doses of Econazole to the Cornea, In Vitro.

DOI：
10.3390/pharmaceutics14081631
发表时间：
2022-08-04
期刊：
PHARMACEUTICS
影响因子：
5.4
作者：
Wong, Anepmete;Fallon, Melissa;Celiksoy, Vildan;Ferla, Salvatore;Varricchio, Carmine;Whitaker, David;Quantock, Andrew J.;Heard, Charles M.
通讯作者：
Heard, Charles M.

The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes