Normal heart development before birth

出生前心脏发育正常

• 批准号: FT170100431
• 负责人: Prof Janna Morrison
• 金额: $ 69.17万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT170100431
• 关键词: Normal; heart; development; before; birth

This project aims to understand how the fetal heart can develop normally with much less oxygen than an adult heart uses. Regulation of fetal heart proliferation is not well understood but changes in oxygen levels and non-coding RNAs are implicated. Using advanced imaging techniques to measure blood flow in blood vessels to the fetal heart and molecular probes to assess cell function and microarrays to measure non-coding RNA, the project expects to generate new knowledge about mechanisms of fetal heart cell proliferation. Ultimately, this new knowledge could lead to non-invasive approaches to detect and treat abnormal fetal heart growth in animals and humans.

该项目旨在了解胎儿心脏如何在比成人心脏使用的氧气少得多的情况下正常发育。胎儿心脏增殖的调节尚不清楚，但氧气水平和非编码 RNA 的变化与之相关。该项目利用先进的成像技术来测量血管中流向胎儿心脏的血流量，并使用分子探针来评估细胞功能，并使用微阵列来测量非编码RNA，该项目期望产生有关胎儿心脏细胞增殖机制的新知识。最终，这一新知识可能会带来非侵入性方法来检测和治疗动物和人类胎儿心脏生长异常。