Opening and closing doors in the fetal circulation impacts brain metabolism

胎儿循环中的门的打开和关闭会影响大脑的新陈代谢

• 批准号: DP220103289
• 负责人: Prof Janna Morrison
• 金额: $ 49.28万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103289
• 关键词: Opening; closing; doors; fetal; circulation

This project aims to measure blood flow from the umbilical cord through special shunts or doors to the fetal brain and to understand how changes in delivery of oxygen may impact fetal brain metabolism. This fundamental phenomenon will be measured with novel MRI protocols developed by a multidisciplinary, international team. Expected outcomes of this project include world-leading advances in measuring fetal blood flow and brain metabolism with exchange of expertise between leading researchers in Australia and Canada and their trainees. In the long-term, this should provide significant benefits in enhancing Australia’s research capacity in fetal physiology and may lead to new tools for monitoring or supporting fetal development.

该项目旨在测量从脐带通过特殊分流器或门到达胎儿大脑的血流量，并了解氧气输送的变化如何影响胎儿大脑的新陈代谢，这一基本现象将通过多学科开发的新型 MRI 方案进行测量。该项目的预期成果包括通过澳大利亚和加拿大领先研究人员及其学员之间的专业知识交流，在测量胎儿血流和脑代谢方面取得世界领先的进展。从长远来看，这将为提高澳大利亚的水平带来重大好处。胎儿研究能力生理学，并可能带来监测或支持胎儿发育的新工具。