Size matters, but at what cost? Role of male sex hormones in the placenta

规模很重要，但代价是什么？

• 批准号: DP240102256
• 负责人: Prof Janna Morrison
• 金额: $ 40万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102256
• 关键词: Size; matters; but; what; cost

This project aims to understand molecular pathways regulated by male sex hormones in the placenta that may contribute to sex-specific fetal growth and survival outcomes in response to reduced oxygen and/or glucose. Through this project, we expect to generate new knowledge of the mechanisms that drive sex-specific placental molecular function using interdisciplinary approaches. The application of this advanced understanding of the sex-specific regulation of placental molecular function and fetal growth may be targeted in future studies to improve fetal growth outcomes in placental mammals such as livestock, domestic pets, and humans.

该项目旨在了解胎盘中男性性激素调节的分子途径，这些途径可能有助于因氧气和/或葡萄糖减少而导致性别特异性胎儿生长和生存结果。通过这个项目，我们希望利用跨学科的方法产生驱动性别特异性胎盘分子功能的机制的新知识。这种对胎盘分子功能和胎儿生长的性别特异性调节的先进理解的应用可能会成为未来研究的目标，以改善胎盘哺乳动物（如家畜、家养宠物和人类）的胎儿生长结果。