AUDITORY ASSESSMENT WITH AEPS IN CHILDREN

儿童 AEPS 听觉评估

• 批准号: 3218131
• 负责人: NINA KRAUS
• 金额: $ 24.54万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3218131
• 关键词: academic achievement; attention deficit disorder; auditory discrimination; auditory threshold; behavior test; child (0-11); diagnosis design /evaluation; electroencephalography; evoked potentials; hearing disorders; hearing tests; human subject; learning disorders; neural information processing; psychoacoustics; sensorineural hearing loss; sleep; speech; speech synthesizers

The overall goal of this investigation is to improve the diagnosis of hearing loss and central auditory deficits in young children. The use of certain auditory evoked potentials (AEPs), including middle latency (MLR) and late potentials, has been limited in pediatric populations because of the variability of these responses during sleep or the dependence of the responses on a behavioral task which may be beyond the capabilities of a young child. This project is an investigation of the MLR and mismatch negativity (MMN) AEPs in children and addresses how these limitations may be overcome. The first major aim is to develop a means to identify the periods during sleep that are favorable for recording the MLR. Previous research has indicated that certain sleep stages are more favorable than others and that they may be distinguished by analyzing the EEG for specific amplitude and frequency characteristics. Proposed is an investigation of the utility of the "delta ratio", a measure of the dominance of delta activity in the EEG. On-line detection of delta presence/absence could signal a clinician or researcher when a child is in a favorable MLR recording period. Similar measures could eventually be applied to other AEPs. A second major aim is to characterize the MMN in response to well-defined speech stimuli to determine if this response can provide an objective neurophysiologic measure of auditory discrimination in school-aged children. The MMN reflects central auditory processing of small acoustic differences and does not depend on active participation from the child. The MMN will be elicited by synthesized speech stimuli that differ in acoustic parameters that are fundamental to speech perception. Another objective is to determine whether developmental changes in the MLR and the MMN correlate with behavioral measures of development as determined by standardized measures of mental aptitude and processes underlying learning and academic achievement. Clinical applicability of the combined electrophysiologic/behavioral approach will be evaluated in (1) children with behaviorally identified central auditory deficits and (2) children with attention deficit hyperactivity disorder -- a group in which the co-existence of auditory processing deficits is well established.

这项调查的总体目的是改善 幼儿的听力损失和中央听觉缺陷。 使用 某些听觉引起的电位（AEP），包括中期潜伏期 （MLR）和较晚的潜力，小儿种群受到限制 由于睡眠或睡眠或 响应对行为任务的依赖性可能超出 小孩的能力。 这个项目是对 MLR和不匹配的负面态度（MMN）AEP在儿童中的AEP，并解决了如何 这些限制可能是克服的。 第一个主要目的是开发一种识别期间期间的手段 有利于记录MLR的睡眠。 先前的研究已有 表明某些睡眠阶段比其他睡眠阶段更有利 可以通过分析特定的脑电图来区分它们 振幅和频率特征。 提议的是调查 “三角洲比”的实用性，这是三角洲的主导地位的衡量标准 脑电图中的活动。 在线检测三角洲的存在/不存在 当孩子处于有利的MLR中时，请发出临床医生或研究人员的信号 记录期。 类似的措施最终可以应用于其他 AEPS。 第二个主要目的是针对明确定义的MMN表征 语音刺激以确定此反应是否可以提供目标 在学龄前的听觉歧视的神经生理测量 孩子们。 MMN反映了小声学的中央听觉处理 差异，不取决于孩子的积极参与。 MMN将通过合成的语音刺激引起 对语音感知至关重要的声学参数。 其他 目的是确定MLR和 MMN与确定的发展行为度量相关 通过标准化的心理能力和过程的衡量标准 学习和学术成就。 临床适用性 将在（1）中评估组合电生理/行为方法 行为上识别出中央听觉缺陷的儿童和（2） 注意力缺陷多动障碍的儿童 - 一组 听觉处理缺陷的共存是很好的 已确立的。