The wheat Diverse MAGIC platform: Community Access to Resources, Protocols and Tools

小麦 Diverse MAGIC 平台：社区获取资源、协议和工具

• 批准号: BB/M011666/1
• 负责人: James Cockram
• 金额: $ 65.98万
• 依托单位: National Institute of Agricultural Botany
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM011666%2F1
• 关键词: wheat; Diverse; MAGIC; platform; Community

ContextWheat is the UK's most important crop, covering 1.6 million hectares and with an annual harvest worth £1.6 billion. Globally, demand for wheat is rising rapidly: it is estimated that by 2050, yield must rise by 60%. The best way to achieve gains in the key wheat breeding targets is to develop improved varieties. The ongoing revolution in genetic and molecular tools for wheat breeding is poised to deliver step changes in wheat genetic gain. However, comparatively little investment has been focused on the development of suitable biological resources to best take advantage of these tools. This project builds on previous publicly-funded investment in a state-of-the-art wheat biological platform: the Multiparent Advanced Generation Inter-Cross (MAGIC) population (termed, 'Diverse MAGIC'). Created over four years by inter-crossing 16 UK wheat varieties over multiple generations, the resulting population of over 600 lines represents a unique resource within the UK and worldwide. By capturing large amounts of genetic variation (from the 16 parents) and efficiently reshuffling these over multiple generations of crossing, the population is well placed to serve as a central resource for a broad spectrum of the UK wheat bioscience community.Aims and objectivesThis project brings together expertise from the plant and animal MAGIC sectors, to develop Diverse MAGIC into an integrated community platform for wheat genetics and breeding. This will be achieved by developing Diverse MAGIC resources, tools and community engagement programs that will enable effective use of Diverse MAGIC within the UK community. Specifically, it will:1) Enlarge the Diverse MAGIC population to 800 lines.2) Provide access to Diverse MAGIC seed.3) Establish a catalogue of genetic and phenotypic variation present in the 16 MAGIC parents.4) Provide baseline field phenotype and high-density genotype data on the whole population.5) Develop bioinformatic and software tools tailored to wheat MAGIC.6) Provide dissemination and training events to promote uptake of MAGIC in wheat.7) Establish and promote Diverse MAGIC 'community phenotyping' events.8) Collate the wheat MAGIC resources generated, and make freely accessible via the project website.Applications and benefitsThe biological and supporting resources generated by this project will stimulate new research, amplify output from existing wheat programs, and aid the translation of scientific discoveries to breeders, farmers and processors. The Diverse MAGIC resource complements existing UK wheat resources for gene validation, and will help promote collaborative research within the crop genetics sector.

背景小麦是英国最重要的作物，面积达 160 万公顷，年收成价值 16 亿英镑。全球对小麦的需求正在迅速增长：预计到 2050 年，产量必须增长 60%。小麦育种的关键目标是开发改良品种。正在进行的小麦育种遗传和分子工具革命有望带来小麦遗传收益的重大变化。然而，针对小麦遗传收益的投资相对较少。开发合适的生物资源，以最好地利用这些工具。该项目建立在之前对最先进的小麦生物平台的公共资助投资之上：多亲代先进一代杂交（MAGIC）群体（称为“”）。 Diverse MAGIC'）通过对 16 个英国小麦品种进行多代杂交而创建，通过捕获大量遗传变异（来自小麦），产生了 600 多个品系，代表了英国和世界范围内的独特资源。 16 个亲本）并通过多代杂交有效地重新调整这些群体，该群体完全有能力成为英国小麦生物科学界广泛领域的中心资源。目的和目标该项目汇集了植物和动物 MAGIC 领域的专业知识，将 Diverse MAGIC 发展成为小麦遗传和育种的综合社区平台。这将通过开发 Diverse MAGIC 资源、工具和社区参与计划来实现，具体而言，这将使 Diverse MAGIC 在英国社区内得到有效利用。将：1) 将 Diverse MAGIC 种群扩大到 800 个品系。2) 提供 Diverse MAGIC 种子的获取途径。3) 建立 16 个 MAGIC 亲本中存在的遗传和表型变异目录。4) 提供基线田间表型和高密度基因型整个人口的数据。5) 开发适合小麦 MAGIC 的生物信息和软件工具。6) 提供传播和培训活动，以促进小麦对 MAGIC 的吸收。7)建立和促进多样化的 MAGIC“社区表型”活动。8) 整理产生的小麦 MAGIC 资源，并通过项目网站免费访问。应用和效益该项目产生的生物和支持资源将刺激新的研究，扩大现有小麦的产量多样化的 MAGIC 资源补充了英国现有的基因验证小麦资源，并将有助于促进作物遗传学领域的合作研究。

项目成果

Effects of breeding history and crop management on the root architecture of wheat

育种史和作物管理对小麦根系结构的影响

• DOI: http://dx.10.1101/2020.02.25.964338
• 发表时间: 2020
• 作者: Fradgley N

TEOSINTE BRANCHED1 Regulates Inflorescence Architecture and Development in Bread Wheat (Triticum aestivum).

TEOSINTE BRANCHED1 调节面包小麦 (Triticum aestivum) 的花序结构和发育。

• DOI: http://dx.10.1105/tpc.17.00961
• 发表时间: 2018
• 期刊: The Plant cell
• 作者: Dixon LE

TEOSINTE BRANCHED1 Regulates Inflorescence Architecture and Development in Bread Wheat (Triticum aestivum).

TEOSINTE BRANCHED1 调节面包小麦 (Triticum aestivum) 的花序结构和发育。

• DOI: http://dx.10.1105/tpc.17.00961
• 发表时间: 2018
• 期刊: The Plant cell
• 作者: Dixon LE

A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat.

大基因组作物基因功能表征的路线图：多倍体小麦的经验教训。

• DOI: http://dx.10.7554/elife.55646
• 发表时间: 2020
• 期刊: eLife
• 影响因子: 7.7
• 作者: Adamski NM

Multi-trait ensemble genomic prediction and simulations of recurrent selection highlight importance of complex trait genetic architecture for long-term genetic gains in wheat

多性状整体基因组预测和循环选择模拟强调了复杂性状遗传结构对于小麦长期遗传增益的重要性

• DOI: http://dx.10.1093/insilicoplants/diad002
• 发表时间: 2023
• 期刊: in silico Plants
• 影响因子: 3.1
• 作者: Fradgley N