US-UK BBSRC-NIFA Collab. Swine Immune Toolkit: Development of new immune reagents for swine health, vaccine and disease studies

美国-英国 BBSRC-NIFA 合作。

• 批准号: BB/M028232/1
• 负责人: Michael Bailey
• 金额: $ 34.01万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM028232%2F1
• 关键词: US; UK; BBSRC; NIFA; Collab.

Pigs are widely reared as food animals in the UK and the US and contribute significantly to both economies. In addition, they are increasingly important in south-east asian economies. However, infectious disease is still a major problem for pig producers: best estimates suggest that the annual costs of swine influenza alone might be between £6-11M from an estimated 10 million pigs to slaughter in the UK alone. Vaccination is a key element in controlling infectious diseases, but relatively few of the vaccines available for pigs provide solid, long-lasting protection for the whole of the vaccinated population. In addition, many of the most important infectious diseases have evolved ways of avoiding normal immunity. Increasingly, therefore, understanding the fundamental mechanisms involved in the immune response to natural infection and to vaccination is becoming important for designing successful vaccines with long commercial lifespans. Similarly, pigs are widely used in biomedical research on human diseases, since they are very close to humans in physiology, size, genetics and immunity. Areas in which pigs are used in research include obesity, heart disease, and infectious diseases.Despite their importance, and despite work over 35 years on developing the tools and reagents to study the pig immune system, we are still a long way behind research in humans and mice, such that we are unable to study some of the newly identified ways in which the immune system works. In some cases this has been because reagents have not been developed, but in some cases the reagents which have been developed have been lost through exclusive commercial agreements or because they were held in a single site and vulnerable to accidents. We propose to identify the gaps in the available reagents and to fill the most important. This will be achieved by canvassing scientists working with pigs worldwide, a process which we have already begun and which has provided us with an initial list of priority targets. The project will develop and validate these reagents and others identified, and share and commercialise them under non-exclusive agreements in order to ensure their continued availability.

猪在英国和美国被广泛饲养作为食用动物，对两国经济做出了重大贡献，此外，它们在东南亚经济中也越来越重要。然而，传染病仍然是生猪生产者的一个主要问题：最佳估计。据估计，仅在英国，每年屠宰 1000 万头猪所造成的猪流感费用就可能在 6 至 1100 万英镑之间。 疫苗接种是控制传染病的关键因素，但可用于猪的疫苗相对较少。持久此外，许多最重要的传染病已经进化出逃避正常免疫的方式，因此，了解对自然感染和疫苗接种的免疫反应的基本机制变得越来越重要。同样，猪被广泛用于人类疾病的生物医学研究，因为它们在生理、体型、遗传和免疫方面与人类非常接近，猪用于研究的领域包括肥胖症、心脏病。 ，并且具有传染性尽管它们很重要，并且尽管我们在开发研究猪免疫系统的工具和试剂方面进行了超过 35 年的工作，但我们仍然落后于人类和小鼠的研究，因此我们无法研究一些新发现的疾病在某些情况下，这是因为尚未开发出试剂，但在某些情况下，已开发的试剂因排他性商业协议而丢失，或者因为它们保存在单一地点并且容易受到影响。我们建议找出差距。这将通过对世界各地与猪合作的科学家进行调查来实现，这一过程为我们提供了初步的优先目标清单，该项目将开发和验证这些目标。试剂和其他确定的试剂，并根据非排他性协议进行共享和商业化，以确保其持续可用。

项目成果

Development and characterization of immune reagents for swine health, vaccine, and disease studies

用于猪健康、疫苗和疾病研究的免疫试剂的开发和表征

• 发表时间: 2017
• 作者: Lunney J

Development and characterization of new immune reagents for swine health, vaccine and disease studies

用于猪健康、疫苗和疾病研究的新型免疫试剂的开发和表征

• 发表时间: 2018
• 作者: Lunney JK

US-UK Collaborative swine immune toolkit initiative: development of new immune reagents for swine health, vaccine and disease studies

美英合作猪免疫工具包倡议：开发用于猪健康、疫苗和疾病研究的新型免疫试剂

• 发表时间: 2015
• 作者: Lunney, JK

Development of new immune reagents for swine health, vaccine and disease studies

开发用于猪健康、疫苗和疾病研究的新型免疫试剂

• 发表时间: 2016
• 作者: Francis O

Development and characterization of reagents recognising swine leucocyte homing receptors

猪白细胞归巢受体识别试剂的开发和表征

• 发表时间: 2018
• 作者: Francis, O