DIAZEPAM, ALCOHOL AND HUMAN INFORMATION PROCESSING

地西泮、酒精和人类信息处理

• 批准号: 3211325
• 负责人: OSCAR A PARSONS
• 金额: $ 17.81万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3211325
• 关键词: afferent nerve; alcoholic beverage consumption; auditory stimulus; brain electrical activity; central nervous system stimulants; cognition; diazepam; drug abuse; efferent nerve; evoked potentials; human subject; male; neural information processing; psychomotor reaction time; psychopharmacology; sensory signal detection; stimulus /response; visual stimulus

The systematic assessment of drug effects in humans using combined measurement of cognitive functioning and brain electrophysiology is a powerful emergent technology. These methods have not been fully exploited in studies of the effects of diazepam or alcohol, two drugs which are commonly abused and often taken together. During this 5-year study of acute dose effects of diazepam and alcohol, jointly acquired behavioral and electrophysiological data will be used to: 1) determine the condition of afferent and efferent pathways, and the cognitive interface between them, 2) identify and localize impairments of specific information- processing operations within the cognitive reaction process, and 3) assess dose-related changes in performance strategies and in the management of cognitive resources. Speed loading and incentive variables will be used to test hypotheses about the mobilization and allocation of energetic resources. These experiments will result in a hierarchically integrated characterization of dose effects of diazepam and alcohol, independently and in combination, on cognition, sensory, motor and electrophysiological functioning in healthy young men. This will provide basic concepts, techniques and a comprehensive data base, with potential application to the systematic assessment of other benzodiazepines as well as other classes of drugs. The resulting account of the dose effects of diazepam and alcohol will fill major gaps in existing knowledge of the independent and combined effects of these drugs on information processing. The results will have predictive generality to the extent that stimulus input processing and response output processing are ubiquitous to most of the cognitive reaction processes invoked by the discrete performance demands encountered in daily human activities.

使用药物对人体的影响进行系统评估 认知功能和大脑的综合测量 电生理学是一项强大的新兴技术。 这些 影响研究中尚未充分利用方法 地西泮或酒精，这两种经常被滥用的药物 经常一起拍摄。 在这项为期 5 年的急性剂量研究中 地西泮和酒精的影响，共同获得的行为和 电生理数据将用于： 1) 确定传入和传出通路的状况， 以及它们之间的认知界面， 2）识别并定位特定信息的缺陷- 认知反应过程中的处理操作，以及 3) 评估表现策略和剂量相关的变化 认知资源的管理。 速度加载和 激励变量将用于检验关于 能源资源的调动和配置。 这些 实验将产生分层集成 地西泮和酒精的剂量效应特征， 独立和组合，关于认知、感觉、运动 和健康年轻男性的电生理功能。 这 将提供基本概念、技术和全面的数据 基础，有可能应用于系统评估 其他苯二氮卓类药物以及其他类别的药物。 地西泮和酒精剂量效应的结果说明 将填补独立和独立的现有知识的主要空白 这些药物对信息处理的综合影响。 这 结果将具有预测普遍性，只要刺激 输入处理和响应输出处理无处不在 大多数认知反应过程都是由离散的 人类日常活动中遇到的性能需求。