DIAZEPAM, ALCOHOL AND HUMAN INFORMATION PROCESSING

地西泮、酒精和人类信息处理

• 批准号: 3211325
• 负责人: OSCAR A PARSONS
• 金额: $ 17.81万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3211325
• 关键词: afferent nerve; alcoholic beverage consumption; auditory stimulus; brain electrical activity; central nervous system stimulants; cognition; diazepam; drug abuse; efferent nerve; evoked potentials; human subject; male; neural information processing; psychomotor reaction time; psychopharmacology; sensory signal detection; stimulus /response; visual stimulus

The systematic assessment of drug effects in humans using combined measurement of cognitive functioning and brain electrophysiology is a powerful emergent technology. These methods have not been fully exploited in studies of the effects of diazepam or alcohol, two drugs which are commonly abused and often taken together. During this 5-year study of acute dose effects of diazepam and alcohol, jointly acquired behavioral and electrophysiological data will be used to: 1) determine the condition of afferent and efferent pathways, and the cognitive interface between them, 2) identify and localize impairments of specific information- processing operations within the cognitive reaction process, and 3) assess dose-related changes in performance strategies and in the management of cognitive resources. Speed loading and incentive variables will be used to test hypotheses about the mobilization and allocation of energetic resources. These experiments will result in a hierarchically integrated characterization of dose effects of diazepam and alcohol, independently and in combination, on cognition, sensory, motor and electrophysiological functioning in healthy young men. This will provide basic concepts, techniques and a comprehensive data base, with potential application to the systematic assessment of other benzodiazepines as well as other classes of drugs. The resulting account of the dose effects of diazepam and alcohol will fill major gaps in existing knowledge of the independent and combined effects of these drugs on information processing. The results will have predictive generality to the extent that stimulus input processing and response output processing are ubiquitous to most of the cognitive reaction processes invoked by the discrete performance demands encountered in daily human activities.

使用的系统评估使用 认知功能和大脑的结合测量 电生理学是一项强大的新兴技术。 这些 方法在研究的影响中尚未完全利用 地西epam或酒精，两种通常被滥用的药物， 经常在一起。 在这项急性剂量的5年研究中 地西ep和酒精的影响，共同获得的行为和 电生理数据将用于： 1）确定传入和传出途径的状况， 以及它们之间的认知接口， 2）识别和本地化特定信息的损害 - 认知反应过程中的处理操作，以及 3）评估与剂量相关的性能策略的变化 认知资源的管理。 速度加载和 激励变量将用于检验有关 动员和分配能量资源。 这些 实验将导致分层集成 地西ep和酒精的剂量作用的表征， 独立和结合，认知，感官，运动 健康的年轻男性和电生理功能。 这 将提供基本概念，技术和全面数据 基础，潜在地应用于系统评估 其他苯二氮卓类药物以及其他类别的药物。 地西ep和酒精的剂量作用的结果说明 将填补独立和现有知识的主要空白 这些药物对信息处理的结合影响。 这 结果将具有预测性的一般性 输入处理和响应输出处理无处不在 离散引用的大多数认知反应过程 日常活动中遇到的绩效需求。