A Nano-platform for affordable and ultra-sensitive bio-marker detection

用于经济实惠且超灵敏的生物标志物检测的纳米平台

• 批准号: LP160101656
• 负责人: Prof Chengzhong Yu
• 金额: $ 20.82万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-10-17 至 2022-10-15
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160101656
• 关键词: Nano; platform; affordable; ultra; sensitive

This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density) will enable higher loading of quantum dots and enhanced detection sensitivity. Improving the detection sensitivity of the inexpensive and disposable LFA diagnostic technology will open up new applications for rapid and accurate biomarker detection. The resulting technology will advance Australian industrial capability and competiveness in the global lateral flow assays market, which is estimated to be valued at US$ 6.78 billion by 2020.

该项目旨在开发下一代纳米平台和Latoral流量测定（LFA），用于生物标志物的超敏感性。具有均匀粒径和可控结构的硅纳米颗粒（孔结构，内部表面功能D）将使量子点和加密的检测灵敏度开放到2020年，全球LATAL低测定市场估计价值为67.8亿美元。