Next-Generation Multifunctional Nanoparticles for mRNA Transfection

用于 mRNA 转染的下一代多功能纳米颗粒

• 批准号: DP200102962
• 负责人: Prof Chengzhong Yu
• 金额: $ 27.73万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-19 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102962
• 关键词: Next; Generation; Multifunctional; Nanoparticles; mRNA

This project aims to engineer a multifunctional nanoparticle platform tailored for mRNA delivery. An innovative assembly approach will be used to design nanoparticles with adjustable composition, asymmetry and surface topography. Uniquely, three functions will be integrated in one nanoparticle, with the goal to enhance transfection efficiency in target cells. This project expects to advance knowledge of mRNA transfection mechanisms, and determine how cell-type dependent particle-mRNA interactions correlate with the nanoparticle structure and delivery performance. Outcomes include a new family of functional materials with improved mRNA delivery performance over benchmark systems to facilitate and broaden the application of mRNA technology.

该项目旨在设计一个针对mRNA输送的多功能纳米颗粒平台。创新的组装方法将用于设计具有可调组成，不对称和表面形态的纳米颗粒。独特的是，将三个功能集成在一个纳米颗粒中，其目标是提高靶细胞的转染效率。该项目期望提高对mRNA转染机制的了解，并确定细胞类型依赖性粒子-MRNA相互作用与纳米颗粒结构和递送性能相关。结果包括一种新的功能材料系列，具有改善基准系统的mRNA传递性能，以促进和扩大mRNA技术的应用。