CASE-CONTROL STUDY OF ADENOCARCINOMA OF THE CERVIX

宫颈腺癌病例对照研究

基本信息

批准号：
3186986
负责人：
RUTH K PETERS
金额：
$ 15.79万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-04-01 至 1992-03-31
项目状态：
已结题

项目摘要

The LONG-TERM OBJECTIVE of this proposal is to conduct a case-control study to investigate the role of oral contraceptives (OC's) in the etiology of adenocarcinoma of the uterine cervix. The SPECIFIC AIMS are (1) to determine if the risk of cervical adenocarcinoma is increased by OC use (especially use before age 20); (2) to determine if risk increases with increasing duration of OC use, decreasing age at first use, or the particular formulation of OC used; (3) to identify other risk factors for this tumor, focusing both on other hormonal exposures such as intrauterine exposure to DES, obesity, and nulliparity, and on risk factors important in squamous cell carcinoma of the cervix such as sexual factors, genital infections, and smoking; (4) to determine if any increased risk due to OC use is modified by other risk factors for this tumor; (5) to determine if any risk factors for this tumor are specific for histologic subcategories of cervical adenocarcinoma; and (6) to establish the reliability of self-reported OC use and self-reported intrauterine exposure to DES. METHODS: A matched case-control study design will be used with two neighborhood controls per case. Case will be 300 English-speaking, white or black women born in 1935 or later, diagnosed with adenocarcinoma of the cervix between 1980 and 1990, and identified by the Los Angeles County/USC Cancer Surveillance Program (CSP). Controls will be matched on sex, race and year of birth (within 3 years). Data will be obtained by personal interviews in subjects; homes using a structured questionnaire and, to facilitate recall, a month-by-month calendar and photo album showing all OC's ever sold in the U.S. Mothers of both cases and controls will be inverviewed by telephone to ascertain intrauterine hormone exposures, and the diagnostic slides of all eligible cases will be requested and re-classified using consistent criteria. Finally, validation of OC use by the prescribing physicians and/or clinics will be requested and this information compared to the self-reported data.

该提案的长期目标是进行病例对照研究研究口服避孕药（OC）在病因学中的作用子宫颈腺癌。具体目标是 (1) 确定使用 OC 是否会增加宫颈腺癌的风险（特别是20岁之前使用）； (2) 确定风险是否随着增加 OC 使用时间、降低首次使用年龄或所用OC的特殊配方； (3) 识别其他危险因素这种肿瘤，重点关注其他激素暴露，例如宫内激素暴露于 DES、肥胖和未生育，以及重要的危险因素子宫颈鳞状细胞癌，如性因素、生殖器感染和吸烟； (4) 确定OC是否会增加风险该肿瘤的其他危险因素改变了使用； (5) 判断是否该肿瘤的任何危险因素都是特定于组织学亚类的宫颈腺癌； (6) 建立可靠性自我报告的 OC 使用和自我报告的 DES 宫内暴露。方法：匹配的病例对照研究设计将采用两个每个案例的邻里控制。案例会300 英语，白色或 1935 年或之后出生、被诊断患有腺癌的黑人女性 1980 年至 1990 年间的子宫颈，并由洛杉矶县/南加州大学鉴定癌症监测计划 (CSP)。控制将根据性别、种族进行匹配以及出生年份（3 年内）。数据将由个人获取专题访谈；使用结构化调查问卷的家庭，方便回忆，每月的日历和相册显示所有 OC 曾经在美国出售过，病例和对照的母亲都将是通过电话询问以确定宫内激素暴露，以及将要求提供所有符合条件的病例的诊断幻灯片，并且使用一致的标准重新分类。最后，验证 OC 使用将要求开处方的医生和/或诊所，并且这信息与自我报告的数据进行比较。