CASE-CONTROL STUDY OF ADENOCARCINOMA OF THE CERVIX

宫颈腺癌病例对照研究

• 批准号: 3186986
• 负责人: RUTH K PETERS
• 金额: $ 15.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3186986
• 关键词: African American; adenocarcinoma; adolescence (12-20); cancer information system; cancer risk; case history; caucasian American; cervical /vaginal smear; cervix neoplasms; diethylstilbestrol; dosage; female antifertility drug; histopathology; interview; neoplasm /cancer diagnosis; obesity; questionnaires; sex behavior; squamous cell carcinoma; tobacco abuse; warts; young adult human (21-34)

The LONG-TERM OBJECTIVE of this proposal is to conduct a case-control study to investigate the role of oral contraceptives (OC's) in the etiology of adenocarcinoma of the uterine cervix. The SPECIFIC AIMS are (1) to determine if the risk of cervical adenocarcinoma is increased by OC use (especially use before age 20); (2) to determine if risk increases with increasing duration of OC use, decreasing age at first use, or the particular formulation of OC used; (3) to identify other risk factors for this tumor, focusing both on other hormonal exposures such as intrauterine exposure to DES, obesity, and nulliparity, and on risk factors important in squamous cell carcinoma of the cervix such as sexual factors, genital infections, and smoking; (4) to determine if any increased risk due to OC use is modified by other risk factors for this tumor; (5) to determine if any risk factors for this tumor are specific for histologic subcategories of cervical adenocarcinoma; and (6) to establish the reliability of self-reported OC use and self-reported intrauterine exposure to DES. METHODS: A matched case-control study design will be used with two neighborhood controls per case. Case will be 300 English-speaking, white or black women born in 1935 or later, diagnosed with adenocarcinoma of the cervix between 1980 and 1990, and identified by the Los Angeles County/USC Cancer Surveillance Program (CSP). Controls will be matched on sex, race and year of birth (within 3 years). Data will be obtained by personal interviews in subjects; homes using a structured questionnaire and, to facilitate recall, a month-by-month calendar and photo album showing all OC's ever sold in the U.S. Mothers of both cases and controls will be inverviewed by telephone to ascertain intrauterine hormone exposures, and the diagnostic slides of all eligible cases will be requested and re-classified using consistent criteria. Finally, validation of OC use by the prescribing physicians and/or clinics will be requested and this information compared to the self-reported data.

该提案的长期目标是进行病例对照研究 研究口服避孕药（OC）在病因中的作用 子宫颈腺癌。 具体目的是（1） 确定OC使用是否增加了宫颈腺癌的风险 （尤其是在20岁之前使用）； （2）确定风险是否随着 OC使用的持续时间增加，初次使用时的年龄降低或 使用的OC的特殊表述； （3）确定其他风险因素 这种肿瘤将两者都集中在其他荷尔蒙暴露上，例如宫内 暴露于DES，肥胖和无效，以及在风险因素上重要 子宫颈的鳞状细胞癌，例如性因素，生殖器 感染和吸烟； （4）确定OC引起的风险是否增加 该肿瘤的其他危险因素改变了使用； （5）确定是否 该肿瘤的任何危险因素都是针对组织学子类别的特定的 宫颈腺癌； （6）建立 自我报告的OC使用和自我报告的宫内暴露于DES。 方法：匹配的病例对照研究设计将与两个 邻里控制每个情况。 案例将为300英语，白色 或1935年或更晚出生的黑人妇女，被诊断出患有腺癌 子宫颈在1980年至1990年之间，并由洛杉矶县/南加州大学确定 癌症监测计划（CSP）。 控件将与性爱，种族匹配 和出生年（3年内）。 数据将通过个人获得 受试者的访谈；房屋使用结构化问卷，然后 便利召回，一个月的日历和相册 OC在美国的母亲曾在案件和控制中出售过 通过电话进行反访问以确定宫内激素暴露，并 将要求所有合格案例的诊断幻灯片，并 使用一致的标准重新分类。 最后，验证OC的使用 将要求开处方医师和/或诊所，这 与自我报告的数据相比。