COMPLETION OF EPIDEMIOLOGIC STUDY OF ANOGENITAL CARCINOM

完成肛门生殖器癌的流行病学研究

基本信息

批准号：
3173303
负责人：
RUTH K PETERS
金额：
$ 11.72万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-09-30 至 1987-12-31
项目状态：
已结题

项目摘要

We propose a three year study to investigate the epidemiology of malignant tumors of the skin and mucous membranes of the anogenital area. Specifically we will focus on epithelial carcinomas of the anus, vulva, and penis. The study is designed to test for multiple antecedent risk factors for these tumors, with special emphasis on sexually transmitted disease and chronic irritation primarily in the form of sexual practices and anogenital conditions and treatments. We plan to use the case-control method. The case group will consist of 400 persons: 100 men and 100 women with squamous or transitional cell carcinomas of the anus or perianal skin, 100 women with squamous cell carcinoma of the vulva, and 100 men with squamous cell carcinoma of the penis. All cases will be identified by the Los Angeles County/USC Cancer Surveillance Program. Controls will be neighborhood controls matched to the cases by date of birth ((plus/minus) 5 years), sex, and race. Data will be obtained by personal interviews (in respondent's homes) by trained interviewers using a structured questionnaire, focusing on the above variables. A 25cc blood specimen will also be collected by the interviewer. Antecedent anogenital conditions which have been medically diagnosed and treated will be verified using hospital and clinical records on the first 25 case-control pairs within each sex-site category, and on all respondents if the verification process proves to provide additional information. In the analysis we will evaluate both the relative importance of each suspected risk factor within each site and sex, and the consistency of findings across sites and sexes.

我们提出一项为期三年的研究来调查恶性疾病的流行病学肛门生殖器区域皮肤和粘膜的肿瘤。具体来说，我们将重点关注肛门、外阴和阴道的上皮癌。阴茎。该研究旨在测试多种先行风险因素对于这些肿瘤，特别强调性传播疾病和主要以性行为和肛门生殖器形式出现的慢性刺激条件和治疗。我们计划使用病例对照方法。这案例组将由 400 人组成：100 名男性和 100 名女性肛门或肛周皮肤的鳞状或移行细胞癌，100 患有外阴鳞状细胞癌的女性和 100 名患有外阴鳞状细胞癌的男性阴茎细胞癌。所有案件都将由洛斯确认安吉利斯县/南加州大学癌症监测计划。控制措施将是邻里控制与出生日期的病例相匹配（（正/负）5 年）、性别和种族。数据将通过个人访谈获得（在受访者的家）由训练有素的访谈员使用结构化的问卷，重点关注上述变量。 25cc 血液样本将也被面试官收集。既往肛门生殖器状况已经过医学诊断和治疗的将使用内前 25 个病例对照对的医院和临床记录每个性爱网站类别，以及所有受访者的验证过程证明可以提供额外的信息。在分析中我们将评估每个地点内每个可疑风险因素的相对重要性和性别，以及跨地点和性别的研究结果的一致性。