CASE CONTROL STUDY OF COLON CARCINOMA

结肠癌病例对照研究

• 批准号: 3174114
• 负责人: RUTH K PETERS
• 金额: $ 25.23万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3174114
• 关键词: adenocarcinoma; body physical activity; cancer information system; cancer risk; case history; caucasian American; dairy products; dietary fiber; dietary lipid; exercise; fats; human middle age (35-64); human subject; meat; nutrition aspect of cancer; nutrition related tag; retinoids; saturated fat; tocopherols; unsaturated fats

A three-year epidemiologic study is proposed to evaluate the respective roles of, and possible interactions between, physical activity and dietary habits in the etiology of adenocarcinoma of the colon. Specifically, the study is designed to test the hypotheses that (a) physical inactivity increases the risk of colon cancer, especially cancers of the left side of the colon, and (b) physical inactivity acts as an effect modifier or as a confounding factor in the relation between dietary factors and colon cancer risk. Dietary habits to be examined include usual past frequency of consumption of (a) fats--total, saturated and polyunsaturated--, (b) beef and all meats, (c) milk and other dairy products, (d) dietary fiber, (e) cruciferous vegetables, and (f) vitamins A, C, ande E. The case-control method will be used. Cases will be all newly diagnosed, eligible cases of adenocarcinoma of the colon identified in residents of Los Angeles County by the Los Angeles County/USC Cancer Surveillance Program during the study period, until 750 cases have been enrolled. Study subjects will be white men and women who speak English and are between the ages of 45 and 69. Controls will be age-, sex-, and raae-matched persons chosen from the neighborhood of the cases using a 1:1 matching design. Data will be obtained by personal interviews in the respondents' home by trained interviewers using a structured, precoded questionnaire. The questionnaire will attempt to assess lifetime physical activity levels (both at work and at leisure) but will emphasize the 30 years prior to the diagnosis of the case. It will also elicit information about specific dietary habits (food frequencies), medical history, and use of drugs (e.g. laxatives, vitamin supplements, etc.). The diet section of the questionnaire will be developed and analysed by the UCLA Diet and Cancer Epidemiology Unit by means of a subcontract to the UCLA School of Public Health.

提出了一项为期三年的流行病学研究，以评估各自的 体育锻炼与饮食之间的作用以及可能的相互作用 结肠腺癌病因的习惯。 具体来说， 研究旨在检验（a）身体不活动的假设 增加了结肠癌的风险，特别是 结肠和（b）物理不活动作为效应修饰符或A 饮食因素与结肠癌之间关系的混杂因素 风险。 待检查的饮食习惯包括通常的过去频率 （a）脂肪的消费 - 量，饱和和多不饱和 - ，（b）牛肉 和所有肉，（c）牛奶和其他乳制品，（d）饮食纤维，（e） 十字花科蔬菜和（F）维生素A，C，Ande E. 将使用病例对照方法。 病例将被新诊断出来， 在 洛杉矶县洛杉矶县/南加州大学癌症监视 在研究期间的计划，直到已注册750例病例。 学习 主题将是会说英语的白人男人和女人 年龄在45和69岁。对照将是年龄，性别和RAAE匹配的人 使用1：1匹配设计从案例附近选择。 数据将通过受访者家中的个人访谈获得 训练有素的访调员使用结构化的，预编码的问卷。 这 问卷将尝试评估终生体育锻炼水平 （无论是在工作还是在闲暇时），但会强调 病例的诊断。 它还将获取有关特定的信息 饮食习惯（食品频率），病史和药物使用（例如 泻药，维生素补充剂等）。 调查表的饮食部分将由 UCLA饮食和癌症流行病学单位通过分包合同 加州大学洛杉矶分校公共卫生学院。