CASE CONTROL STUDY OF COLON CARCINOMA

结肠癌病例对照研究

• 批准号: 3174114
• 负责人: RUTH K PETERS
• 金额: $ 25.23万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3174114
• 关键词: adenocarcinoma; body physical activity; cancer information system; cancer risk; case history; caucasian American; dairy products; dietary fiber; dietary lipid; exercise; fats; human middle age (35-64); human subject; meat; nutrition aspect of cancer; nutrition related tag; retinoids; saturated fat; tocopherols; unsaturated fats

A three-year epidemiologic study is proposed to evaluate the respective roles of, and possible interactions between, physical activity and dietary habits in the etiology of adenocarcinoma of the colon. Specifically, the study is designed to test the hypotheses that (a) physical inactivity increases the risk of colon cancer, especially cancers of the left side of the colon, and (b) physical inactivity acts as an effect modifier or as a confounding factor in the relation between dietary factors and colon cancer risk. Dietary habits to be examined include usual past frequency of consumption of (a) fats--total, saturated and polyunsaturated--, (b) beef and all meats, (c) milk and other dairy products, (d) dietary fiber, (e) cruciferous vegetables, and (f) vitamins A, C, ande E. The case-control method will be used. Cases will be all newly diagnosed, eligible cases of adenocarcinoma of the colon identified in residents of Los Angeles County by the Los Angeles County/USC Cancer Surveillance Program during the study period, until 750 cases have been enrolled. Study subjects will be white men and women who speak English and are between the ages of 45 and 69. Controls will be age-, sex-, and raae-matched persons chosen from the neighborhood of the cases using a 1:1 matching design. Data will be obtained by personal interviews in the respondents' home by trained interviewers using a structured, precoded questionnaire. The questionnaire will attempt to assess lifetime physical activity levels (both at work and at leisure) but will emphasize the 30 years prior to the diagnosis of the case. It will also elicit information about specific dietary habits (food frequencies), medical history, and use of drugs (e.g. laxatives, vitamin supplements, etc.). The diet section of the questionnaire will be developed and analysed by the UCLA Diet and Cancer Epidemiology Unit by means of a subcontract to the UCLA School of Public Health.

建议进行一项为期三年的流行病学研究来评估各自的情况 体力活动和饮食之间的作用以及可能的相互作用 结肠腺癌病因学的习惯。 具体来说， 研究旨在检验以下假设：(a) 缺乏身体活动 增加患结肠癌的风险，尤其是左侧结肠癌 结肠，以及（b）身体不活动作为效果调节剂或作为 饮食因素与结肠癌关系中的混杂因素 风险。 要检查的饮食习惯包括过去的平常频率 (a) 脂肪——总脂肪、饱和脂肪和多不饱和脂肪——的消费量，(b) 牛肉 和所有肉类，(c) 牛奶和其他乳制品，(d) 膳食纤维，(e) 十字花科蔬菜，以及 (f) 维生素 A、C 和 E。 将使用病例对照方法。 病例全部为新确诊病例， 在居民中发现的符合条件的结肠腺癌病例 洛杉矶县/南加州大学癌症监测中心 计划在研究期间，直至已入组750例。 学习 受试者将是讲英语且介于两者之间的白人男性和女性 年龄在 45 岁和 69 岁之间。对照是年龄、性别和 raae 匹配的人 使用 1:1 匹配设计从案例的邻域中选择。 数据将通过在受访者家中进行个人访谈的方式获得 使用结构化、预编码的调查问卷对访谈员进行培训。 这 调查问卷将尝试评估终生身体活动水平 （工作和休闲时）但会强调 30 年前 病例的诊断。 它还将引出有关特定信息 饮食习惯（食物频率）、病史和药物使用（例如， 泻药、维生素补充剂等）。 调查问卷的饮食部分将由以下人员制定和分析： 加州大学洛杉矶分校饮食和癌症流行病学单位通过分包给 加州大学洛杉矶分校公共卫生学院。