TOTAL SYNTHESIS OF ANTITUMOR TAXANES

抗肿瘤紫杉烷的全合成

• 批准号: 3182770
• 负责人: ROBERT A HOLTON
• 金额: $ 16.85万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-06-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3182770
• 关键词: diterpenes; drug design /synthesis /production; plant extracts; respiratory oxygenation

The aim of this research is to develop synthetic methodologoy which will permit the development of a short and efficient general synthesis of antitumor taxanes. Several of these have been shown to be potent antitumor substances and one (taxol) is currently in clinical trials. Successful completion of this project will provide an abundant supply of taxol, as well as providing synthetic analogs which will be available for testing as antitumor agents. This project is also designed to provide new synthetic methodology which will be of general utility in the field of chemical synthesis.

本研究的目的是开发合成方法，该方法将 允许开发短而有效的通用合成 抗肿瘤紫杉烷类药物。 其中一些已被证明具有有效的抗肿瘤作用 其中一种物质（紫杉醇）目前正在进行临床试验。 该项目的顺利完成将为 紫杉醇，以及提供合成类似物，可用于 作为抗肿瘤剂进行测试。 该项目还旨在提供新的 合成方法将在以下领域具有普遍实用性 化学合成。