TOTAL SYNTHESIS OF APHIDICOLN, A POTENT ANTITUMOR AGENT

强效抗肿瘤剂 AphidicolN 的全合成

• 批准号: 3182755
• 负责人: ROBERT A HOLTON
• 金额: $ 5.67万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-06-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3182755
• 关键词: antifungal agents; diterpenes; drug design /synthesis /production; drug screening /evaluation

The aim of this research is to develop synthetic methodology involving a new double Michael cyclization and chirality transfer which will allow the antitumor agent Aphidicolin to be synthesized in an efficient manner. Successful completion of this project will provide a method for the production of an abundant supply of this promising new drug, as well as providing synthetic analogs which will be available for testing as antitumor and antimitotic agents. This project is designed to provide new synthetic methodology which will be of general utility in the field of chemical synthesis.

本研究的目的是开发涉及以下内容的合成方法： 新的双迈克尔环化和手性转移，这将允许 以有效的方式合成抗肿瘤剂Aphidicolin。 该项目的成功完成将为 生产这种有前途的新药的充足供应，以及 提供合成类似物，可用于测试 抗肿瘤剂和抗有丝分裂剂。 该项目旨在提供新 合成方法将在以下领域具有普遍实用性 化学合成。