MULTISITE PO2 MEASUREMENTS

多站点 PO2 测量

• 批准号: 6123394
• 负责人: Oleg Grinberg
• 金额: $ 1.95万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123394
• 关键词: Mammalia; biomedical resource; building /facility design /renovation; gas; technology /technique

While in principle EPR imaging can provide a comprehensive description of the distribution of pO2, this approach usually is limited by the sensitivity of EPR measurements. Localized EPR spectroscopy with particulate materials can provide long term measurements of pO2 in tissue at several sites simultaneously. Magnetic field gradients along X-, Y- and Z-axises were used to resolve EPR spectra from several different sites simultaneously. Using rat hearts and tumors with placement of pieces of material at a distance six or more times the size of the pieces themselves (no matter what kind of material is used), multisite measurements of pO2 (up to eight sites) have been carried out. For example, with LiPc crystals of about 0.5mm in size, sites separated by 3mm or more could be readily followed.

虽然原则上 EPR 成像可以提供全面的 描述 pO2 的分布，这种方法通常是 受 EPR 测量灵敏度的限制。 本地化EPR 颗粒材料的光谱可以提供长期 同时测量多个部位组织中的 pO2。 沿 X、Y 和 Z 轴的磁场梯度用于 同时解析来自多个不同位点的 EPR 谱。 使用大鼠心脏和肿瘤，将材料块放置在 距离是碎片本身尺寸的六倍或更多倍（没有 无论使用哪种材料），pO2 的多点测量 （最多八个地点）已进行。 例如，使用 LiPc 晶体大小约为0.5毫米，位点间隔3毫米或以上 很容易被跟随。