MARINE ANIMAL ANTINEOPLASTIC CONSTITUENTS

海洋动物抗肿瘤成分

• 批准号: 3164334
• 负责人: GEORGE R PETTIT
• 金额: $ 21.13万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3164334
• 关键词: animal colony; autoradiography; biomedical facility; bladder neoplasm; cancer information system; cancer prevention; cancer registry /resource; cancer rehabilitation /care; comprehensive care; cryopreservation; densitometry; electron microscopy; flow cytometry; growth media; health science research analysis /evaluation; histopathology; human subject; information retrieval; kidney neoplasms; literature survey; medical education; microorganism culture; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer epidemiology; neoplasm /cancer immunodiagnosis; neoplasm /cancer immunotherapy; prostate neoplasms; radiobiology; scanning electron microscopy; tissue /cell culture; tissue /organ preservation

A long-term study directed at the isolation, characterization and structural elucidation of new and potentially useful cancer chemotherapeutic drugs from marine animals has been proposed. Support would be used to isolate and characterize anti-cancer agents from confirmed active extracts of marine invertebrates, and marine vertebrates. Maximum effort would be devoted to marine animal species affording extracts with outstanding confirmed level activity (T/C greater than 150) in the National Cancer Institute's murine PS lymphocytic leukemia screening system. As each problem is solved (or placed in a lower priority due to decreasing or lost activity during fractionation guided by bioassay) it would be replaced by another (of high priority) from a current collection of over 300 marine animal specied giving extracts with a confirmed level of activity. The lower animals represent an exceedingly productive source of new cancer chemotherapeutic drugs and all effort will be directed at making such new substances available to the Division of Cancer Treatment, National Cancer Institute.

一项针对隔离，表征和的长期研究 新的和潜在有用的癌症的结构阐明 已经提出了来自海洋动物的化学治疗药物。 支持 将用于隔离和表征与确认的抗癌剂 海洋无脊椎动物和海洋脊椎动物的活性提取物。 最大限度 努力将专门用于海洋动物物种，提供提取物 全国范围 癌症研究所的鼠PS淋巴细胞性白血病筛查系统。 作为 解决了每个问题（由于减少或 分馏过程中的活动损失由生物测定指导）将被替换 当前收集300多名海军陆战队的另一个（优先级）的另一个（优先级） 动物指定的提取物具有确认的活性水平。 这 下动物代表了新癌症的极其有效的来源 化学治疗药物和所有努力将致力于制造这种新的 癌症治疗分区的物质，国家癌症 研究所。