CORE--BURN TRAUMA CENTER

核心--烧伤中心

• 批准号: 6240398
• 负责人: RONALD GARY TOMPKINS
• 金额: $ 44.37万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6240398
• 关键词: analytical chemistry; animal colony; autoradiography; biomedical equipment resource; biomedical facility; burn therapy; burns; chemical synthesis; confocal scanning microscopy; electron microscopy; human subject; mass spectrometry; method development; molecular biology; nuclear magnetic resonance spectroscopy; statistics /biometry

The Research Core plays a major role in the planning and coordination of resources, equipment, and investigations to be performed in the Burn Trauma Center. The areas of research being studied by the Burn Trauma Center are complimentary and because the senior investigators have worked together effectively and productively in the past, the proposed investigations pose an unusual opportunity to utilize the considerable benefits of a common core facility which are the following: 1) use of shared major equipment; 2) standardization of commonly used research protocols and procedures; 3) a unified, very experienced clinical research staff allowing careful quality control and attention to safety and comfort issues in all human studies; 4) centralized preparation, quality control, and attention to the animal welfare aspects of animal models; 5) standardized performance and quality control of bioassay, biochemical, molecular, metabolic, and immunochemical techniques for all in vitro, human and animal studies. The Research Core provides the centralized focus, eliminates duplication, insures quality and attention to detail. Further, the Research Core provides a central and effective mechanism to oversee and coordinate studies insuring that the research groups and projects involved in the studies are, in fact, all focused on the same problem, at the same time in the same patient or animal. In addition the Research Core personnel involved in the human studies insure patient comfort, patient safety, as well as study accuracy. We have developed an efficient system over the past years of Burn Trauma Center to obtain a high degree of effectiveness in the areas noted above using the Research Core as the central focus of all collaborative studies. Our experience with this system demonstrates that we have been able to utilize resources to advantage achieving a higher reproducibility, equipment utilization, and specialized investigator skills working as a Burn Trauma Center than would be expected in research projects in isolation. The Research Core therefore, although not containing research projects in itself, is of key importance to patient safety, animal welfare, and overall accuracy, efficiency and productivity of our Burn Trauma Center.

研究核心在计划和协调中起着重要作用 在燃烧中进行的资源，设备和调查 创伤中心。 烧伤创伤研究的研究领域 中心是免费的，因为高级调查员已经工作了 过去有效，有效地共同提议 调查带来了一个不寻常的机会来利用大量 共同核心设施的好处，如下：1） 共享主要设备； 2）常用研究的标准化 协议和程序； 3）一个统一，经验丰富的临床 研究人员允许仔细的质量控制和关注安全 和所有人类研究中的舒适问题； 4）集中准备， 质量控制以及对动物动物福利方面的关注 模型； 5）生物测定的标准化性能和质量控制， 所有人的生化，分子，代谢和免疫化学技术 体外，人类和动物研究。 研究核心提供了 集中关注，消除重复，确保质量和关注 详细说明。 此外，研究核心提供了一个中心有效的 监督和协调研究确保研究的机制 实际上，参与研究的小组和项目都集中在 同一时间，同时在同一患者或动物中。 在 加上参与人类研究的研究核心人员保证 患者舒适，患者的安全以及学习准确性。 我们有 在过去几年的烧伤创伤中心开发了一个高效的系统 为了在上述区域中获得高度的有效性 研究核心是所有协作研究的中心重点。 我们的 该系统的经验表明，我们已经能够 利用资源来实现更高的可重复性， 设备利用和专业研究者技能 烧伤创伤中心比研究项目中预期的 隔离。 因此，研究核心尽管不包含研究 项目本身对于患者安全，动物至关重要 福利以及燃烧的总体准确性，效率和生产力 创伤中心。