CORE GRANT FOR VISION RESEARCH

愿景研究核心资助

• 批准号: 3102620
• 负责人: GORDON KENNETH KLINTWORTH
• 金额: $ 15.13万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-03-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3102620
• 关键词: animal colony; autoradiography; biomedical facility; electron microscopy; eye; eye disorder; histochemistry /cytochemistry; histology; immunochemistry; immunologic assay /test; tissue /cell culture

The primary objectives of this grant are to strengthen ongoing collaborative research activities and stimulate new interdisciplinary and interdepartmental research by providing core support for several modules to be made available as common research facilities to investigators of Vision and its Disorders. These modules include: an animal surgery suite, a morphologic module, a biochemistry module, an immunology module, a tissue culture module, and an administrative module. These facilities provide services and shared resources for collaborative studies on eye related research projects that conform with the NEI national research plan. The various modules will enable us to strengthen our collaborative efforts among scientists of various disciplines in the Departments of Ophthalmology, Anatomy, Pathology, Immunology, Biochemistry, Zoology, Medicine, Radiology and Psychology. The Animal Surgery module will foster collaborative research by making it possible for investigators from diverse disciplines to carry out surgery and experiments together in a facility specifically designed and equipped for ophthalmic procedures in an Eye Center in which basic scientists and clinical ophthalmologists work in harmony. The Ocular Morphology module with its components in the Departments of Anatomy and Ophthalmology will provide services enabling co-investigators from different disciplines to correlate histologic, autoradiographic and ultrastructural observations with biochemical, physiological or clinical alterations in ocular disease. The Tissue Culture module will enable clinical and basic scientists to prepare cell lines established for a variety of experiments that employ cell culture methodology. The Immunology module will provide assistance to investigators who are not experts in immunology in producing conventional and monoclonal antibodies by technicians specially trained in these procedures. This module will also provide facilities for immunoflourescent and immunoperoxidase staining of tissue sections. The Administrative module will coordinate the various eye related research activities and provide the necessary resources for the administration of the Core Grant.

这笔赠款的主要目标是加强持续的 协作研究活动并刺激新的跨学科和 部门间研究通过为多个模块提供核心支持 可以作为远见研究者作为常见研究设施提供 及其疾病。 这些模块包括：动物手术套件， 形态学模块，生物化学模块，免疫学模块，组织 文化模块和管理模块。 这些设施提供 服务和共享资源用于与眼睛有关的协作研究 符合NEI国家研究计划的研究项目。 这 各种模块将使我们能够加强我们的协作努力 在各个学科的科学家中 眼科，解剖学，病理学，免疫学，生物化学，动物学， 医学，放射学和心理学。 动物手术模块将促进 合作研究通过使来自不同的调查员成为可能 学科在设施中一起进行手术和实验 专门设计和配备了眼睛的眼科手术 基础科学家和临床眼科医生在其中工作的中心 和谐。 眼部形态模块及其组成部分 解剖学和眼科部门将提供启用的服务 从不同学科的共同评估者与组织学相关， 带有生化的放射自显影和超微结构观察 眼部疾病的生理或临床改变。 组织 文化模块将使临床和基本科学家能够准备细胞 为采用细胞培养的各种实验建立的线 方法论。 免疫学模块将为 不是免疫学专家的调查人员 和受过专门培训的技术人员的单克隆抗体 程序。 该模块还将为免疫燃料提供设施 组织切片的免疫过氧化物酶染色。 行政 模块将协调各种相关的研究活动，并 为管理核心赠款提供必要的资源。