DISTRUPTED SLEEP IN THE ELDERLY--CIRCADIAN ETIOLOGY

老年人睡眠障碍——昼夜节律病因

• 批准号: 3116853
• 负责人: Charles A Czeisler
• 金额: $ 12.41万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1986-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3116853
• 关键词: aging; biological clocks; bioperiodicity; blood chemistry; body temperature; chronotherapy; circadian rhythms; cortisol; electroencephalography; human middle age (35-64); human old age (65+); sleep; sleep disorders; urinalysis; visible light; young adult human (21-34)

It is generally appreciated that sleep-wake habits change with age. The most consistent such change is the advance of the sleep period to earlier bedtimes an earlier arising times. In addition, older individuals often report and "assymmetric" disruption of sleep, consistent with a shift of the underlying rhythm controlling sleep to an earlier time of day. Similar changes in the circadian rhythms of REM sleep and body temperature support the central hypothesis that the phase of the circadian system advances to an earlier time with increased age. On the basis of simulations using the "dual-oscillator" model of human circadian rhythms, three testable hypotheses are proposed: 1) that the phase advance of sleep reflects an underlying phase advance of the "deep" circadian oscillator; 2) that this phase advance under entrained conditions is a consequence of an age-dependent decrease in the free-running period of the deep oscillator; and 3) that amplification of normal entraining stimuli can reverse this phase advance and the consequent sleep disturbance. A series of experiments are proposed utilizing new methodologies that allow direct measurement of deep oscillator phase and period. These experiments will accomplish four specific aims: 1) quantification of an age-dependent change in circadian phase; 2) documentation of its role as the pathophysiologic mechanism in a subset of age-related sleep disturbances; 3) elucidation of the mechanism underlying the altered phase relations; and 4) evaluation of a potential non-drug therapy for age-related sleep disruption. This work has significant implications for circadian oscillator theory as well as for gerontologic medicine. Age-related changes in the circadian system have been etiologically implicated in the increased prevalence of depression and disorders of thermoregulation (hypothermia) among the aged. Greater understanding of circadian mechanisms and their age-dependent alteration, as well as the development of non-invasive methods for reversing this alteration, offer substantive promise for improved health of the elderly.

人们普遍认为睡眠习惯随着年龄的增长而改变。 这 最一致的改变是睡眠期的发展 睡觉的时间较早。 另外，老年人经常 报告和睡眠中断的“对称”破坏，与转移一致 控制睡眠的基本节奏至一天中的早期。 相似的 REM睡眠和体温支持的昼夜节律的变化 圆形系统阶段发展到的核心假设 年龄增加的时间。 基于使用人类的“双振荡器”模型的模拟 昼夜节律，提出了三个可检验的假设：1） 睡眠的阶段进展反映了“深”的基本阶段进步 昼夜节律振荡器； 2）此阶段在夹带条件下进步 是由于年龄依赖于年龄段下降的结果 深振荡器； 3）正常插入刺激的扩增 可以扭转这一阶段的进步以及随之而来的睡眠障碍。 提出了一系列实验，利用了允许的新方法 直接测量深振荡器阶段和周期。 这些实验 将实现四个特定目标：1）定量年龄依赖性 昼夜节律变化； 2）记录其角色 与年龄相关的睡眠障碍子集中的病理生理机制； 3）阐明改变相位关系的机制；和 4）评估与年龄相关睡眠的潜在非药物治疗 破坏。 这项工作对昼夜节律理论具有重要意义 以及老年医学。 昼夜节律与年龄有关的变化 系统在病因上与增加的患病率有关 老年人中体温调节（体温过低）的抑郁症和疾病。 对昼夜节学机制及其年龄依赖性的更多了解 改变以及开发非侵入性方法 扭转这种改动，为改善健康的实质性承诺提供 老人。