NITRIC OXIDE IN STROKE--STRATEGIES FOR NEUROPROTECTION

中风中的一氧化氮——神经保护策略

• 批准号: 2751050
• 负责人: David M. Armstrong
• 金额: $ 0.34万
• 依托单位: ALLEGHENY-SINGER RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-11-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2751050
• 关键词: disease /disorder model; electron spin resonance spectroscopy; enzyme inhibitors; glutamate receptor; glutamates; immunocytochemistry; laboratory rat; neuroprotectants; nitric oxide; nitric oxide synthase; stroke

This application is an extension of a grant that examines some of the molecular events associated with focal brain ischemia. The parent grant hypothesized that there is an alteration of calcium-dependent enzymes and glutamate receptors in ischemic-damaged cortical regions. Using the same stroke model, the FIRCA proposal will examine alterations in nitric oxide concentration, as well as putative activity changes in specific sub-species of nitric-oxide synthase enzymes that may be responsible for the altered NO concentrations.

该申请是一项补助金的延伸，审查了一些 与局灶性脑缺血相关的分子事件。 家长 格兰特假设钙依赖性发生了改变 缺血损伤皮质中的酶和谷氨酸受体 地区。 使用相同的中风模型，FIRCA 提案将 检查一氧化氮浓度的变化，以及假定的 一氧化氮合酶特定亚种的活性变化 可能导致 NO 浓度改变的酶。