NEUROBIOLOGY OF CHRONIC MUSCLE PAIN

慢性肌肉疼痛的神经生物学

• 批准号: 6394319
• 负责人: KATHLEEN A SLUKA
• 金额: $ 17.2万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-26 至 2004-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394319
• 关键词: acidity /alkalinity; chronic disease /disorder; disease /disorder model; dorsal horn; fibromyalgia; glutamate receptor; heat injury; hyperalgesia; injection /infusion; laboratory rat; model design /development; neurobiology; neurons

DESCRIPTION (taken from the application): Although 14% of the United States population suffers from chronic musculoskeletal pain, most of our knowledge about pain has been obtained from studies on cutaneous pain. The current models of musculoskeletal pain typically produce short term hyperalgesia (resolved in 24 h or less). However, clinically, chronic muscle pain, as experienced by people with fibromyalgia, is long lasting (months to years). In preliminary studies, I determined that a long lasting bilateral hyperalgesia can be induced by two injections of low pH saline, five days apart, into one gastrocnemius muscle. In the work proposed I hypothesize that the development of the long lasting bilateral hyperalgesia is dependent initially on input from the site of injection following both the first and second injection. I further propose that once the long lasting hyperalgesia develops plastic changes in the central nervous system occur that maintain the hyperalgesia through increased activity in spinal neurons. The specific aims will establish and characterize a new model of muscle pain that is chronic and widespread. The proposed studies will establish if the neural mechanisms involved in the development and maintenance of chronic pain, induced by stimulation of muscle nociceptors, involve peripheral or central nervous system processes. These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain.

描述（摘自应用程序）： 尽管14%的美国人口患有慢性病 肌肉骨骼疼痛，我们关于疼痛的大部分知识都是从 皮肤疼痛的研究。目前的肌肉骨骼疼痛模型通常 产生短期痛觉过敏（24 小时或更短时间内缓解）。然而， 临床上，纤维肌痛患者所经历的慢性肌肉疼痛是 持久（数月至数年）。在初步研究中，我确定 两次注射低 pH 值可引起持久的双侧痛觉过敏 将盐水注入一侧腓肠肌，间隔五天。在我提出的工作中 假设长期持续的双侧痛觉过敏的发展是 最初取决于注射部位的输入 第一次和第二次注射。我进一步建议，一旦长期 痛觉过敏会导致中枢神经系统发生塑性变化 通过增加脊髓神经元的活动来维持痛觉过敏。这 具体目标将建立并描述一种新的肌肉疼痛模型， 是长期且广泛存在的。拟议的研究将确定神经是否 涉及慢性疼痛的发展和维持的机制，诱发 通过刺激肌肉伤害感受器，涉及周围或中枢神经 系统进程。这些拟议的研究将有助于理解和 因此，慢性肌肉疼痛的潜在治疗方法，包括以下病症 纤维肌痛、肌筋膜疼痛和腰痛。