INTERDISCIPLINARY RESEARCH--IMMUNOLOGIC DISEASE

跨学科研究--免疫疾病

• 批准号: 3105096
• 负责人: JOSEPH Alphonso BELLANTI
• 金额: $ 51.47万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105096
• 关键词: growth /development; immunity; immunopathology

The proposed Center Grant is a request for continued CIRID funding of an ongoing Center for Interdisciplinary Studies of Immunology at Georgetown. The Center exists as a functionally recognized unit of the University and has integrated programs in research, education and patient care, as well as in community, outreach, technology transfer and education. The overall proposed program project consists of senior investigators representing basic science and clinical disciplines (pediatrics, medicine, neurology, biochemistry, microbiology, biostatistics, and community medicine) all of whom have pooled their expertise and resources in the present CIRID grant proposal. The present proposal has been significantly revised and has been prepared as a program project grant and includes five interrelated, interdependent research projects. Four of the project (1-4) interact around a central unifying theme of maturational immunologic processes in the developing host and their role in antimicrobial host defense. The broad hypothesis to be examined is that deficiency or impairment in development in any of a number of nonspecific and specific immunologic parameters can lead to immunologic compromise and predispose the developing host to severe infection and disease. The projects range from studies of the development of phagocytic function in the neonate (Project 1), structural and functional studies of the third component of complement (Project 2), developmental studies of the secretory IgA system (Project 3), studies of the developing immune system on responses to viral and myelin antigens (Project 4); a fifth project community outreach technology transfer and education includes a pediatric asthma patient education project utilizing self-management techniques.

拟议的中心赠款是持续CIRID资金的请求 正在进行的免疫学跨学科研究中心 在乔治敦。 该中心作为功能识别的单元存在 大学的研究，并在研究中综合计划， 教育和患者护理以及社区，外展， 技术转移和教育。 总体建议的计划 项目由代表基础科学的高级调查员组成 和临床学科（儿科，医学，神经病学， 生物化学，微生物学，生物统计学和社区医学） 所有人都将他们的专业知识和资源集中在 目前的CIRID赠款提案。 目前的提议已经 大量修订并已作为计划项目准备 赠款，包括五个相互关联的相互依存研究 项目。 该项目的四个（1-4）围绕中央互动 成熟免疫过程的统一主题 发展宿主及其在抗菌宿主防御中的作用。 这 要研究的广泛假设是缺乏或障碍 在许多非特异性和特定的 免疫学参数可能导致免疫学妥协，并 易患严重感染和疾病的宿主。 项目范围从研究的研究 在新生儿（项目1），结构和功能中的功能 对补体的第三部分的研究（项目2）， 分泌IgA系统的发展研究（项目3）， 对发展免疫系统的研究对病毒和病毒的反应 髓磷脂抗原（项目4）；第五个项目社区宣传 技术转移和教育包括儿科哮喘 使用自我管理技术的患者教育项目。