OTITIS MEDIA RESEARCH CENTER

奥蒂斯媒体研究中心

• 批准号: 3099598
• 负责人: CHARLES D BLUESTONE
• 金额: $ 5.48万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1985-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099598
• 关键词: child (0-11); human subject; otitis media

Otitis media (OM) is the most common diagnosis made by physicians who care for children, constituting a major health problem in this country. In addition, the state of the knowledge on the subject of OM is lacking in many respects. The epidemiology, natural history, pathogenesis, etiology, diagnosis, management and outcomes of OM are not well established and a significant amount of work lies ahead before these areas can be defined and understood. With this application the University of Pittsburgh -- specifically the Children's Hospital of Pittsburgh (CHP) -- is proposing to establish an Otitis Media Research Center. The core of the proposed center is a series of clinical research studies variously designed to study the efficacy of treatments of OM according to disease stage: acute, recurrent acute and chronic OM with effusion. Some of these clinical studies are currently in progress at CHP, while funding is being sought for others. In addition to these projects are twelve integrated but independent Center projects dealing with various aspects of OM. Preliminary work in these project areas has been well established by the investigators and will form the basis of each proposal. The proposed Center will allow: basic scientists to interact with clinician-scientists in a more intense and formal manner than possible in the past; important questions regarding OM to be answered in an organized manner; patients to flow smoothly from one study to the next depending upon disease stage; the research team to concentrate on research for a reasonable period with financial support; an opportunity to conduct studies, analyze data and publish findings, all leading to the next steps in the development of an organized research approach; this research to be accomplished at a funding level significantly lower than that required for individual research efforts. The presence in Pittsburgh of an experienced, committed research team coupled with the facts that the institutions involved have demonstrated support, adequate clinical and basic research facilities are available, a sufficient number of subjects is attainable, and that patient referral patterns are well established all clearly suggests that the proper time for establishing an Otitis Media Research Center is the present.

中耳炎培养基（OM）是医生所做的最常见的诊断 儿童，构成这个国家的主要健康问题。 另外， 在许多方面，缺乏关于OM主题的知识状态。 这 流行病学，自然病史，发病机理，病因学，诊断，管理和 OM的成果还没有很好地确定，大量工作在于 在这些领域的定义和理解之前。 使用此应用程序 匹兹堡大学 - 特别是儿童医院 匹兹堡（CHP） - 提议建立一个中耳炎媒体研究中心。 拟议中心的核心是一系列临床研究 各种设计用于研究OM治疗的功效 疾病阶段：急性，复发性急性和慢性OM带积液。 其中一些 这些临床研究目前正在CHP进行，而资金正在 为他人寻求。 除了这些项目外，还集成了十二个 独立的中心项目处理OM的各个方面。 初步的 研究人员已经确定了这些项目领域的工作 将构成每个建议的基础。 拟议的中心将允许：基本 科学家在更激烈，更正式的情况下与临床医生互动 过去的方式关于OM的重要问题 以有组织的方式回答；患者从一项研究顺利流动到 接下来取决于疾病阶段；研究团队专注于研究 在合理的期间，经济支持；进行进行的机会 研究，分析数据和发布发现，所有这些都导致了下一步 开发有组织的研究方法；这项研究要完成 在资金级别上明显低于个人所需的资金 研究工作。 在匹兹堡的存在，有经验丰富的承诺 研究团队以及所涉及的机构的事实 表现出支持，足够的临床和基础研究设施是 可用，可以实现足够数量的受试者，该患者 转介模式已得到充分确立，所有这些都清楚地表明了适当的时间 目前是建立中耳炎媒体研究中心。