OTITIS MEDIA RESEARCH CENTER

奥蒂斯媒体研究中心

• 批准号: 3094776
• 负责人: CHARLES D BLUESTONE
• 金额: $ 166.82万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-30 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3094776
• 关键词: child (0-11); human subject; otitis media

Otitis media (OM) is the most common illness for which children receive medical care in this country. Approximately $2 billion are spent annually on medical and surgical treatment. On Oct 80, the Otitis Media Research Center was established at the Children's Hospital of Pittsburgh which is focused into five clinical trials and six laboratory/clinical studies in humans and animals. Clinical trials are designed to determine the most effective method of management/prevention of infants and children with acute and recurrent acute OM, and otitis media with effusion (OME). Over 1,800 subjects have entered into the clinical trials. Decongestant and antihistamine (D&A) therapy lacks efficacy for OME, but amoxicillin (without D&A) therapy is effective for OME. Efficacy of other antimicrobial agents (and combinations) is being tested and will continue. Our trials of myringotomy and myringotomy with tympanostomy tube (M&T) for chronic OME indicate that M&T does provide children with less morbidity, but perforation of the tympanic membrane is a complication; final two years treatment/observation needed. Prophylaxis of recurrent acute OM (antimicrobials or M&T) will require further treatment/observation before final outcome is known, and adenoidectomy with and without tonsillectomy (T&A) will require more subjects enrolled and treated/observed to determine outcomes. The trial of antimicrobial therapy/myringotomy for acute OM will be completed as planned. Laboratory/clinical studies include: studies of cross-sectional anatomy and computer imaging of histological and histopathologic specimens of the Eustachian tube (ET) and temporal bone; biochemical and enzyme composition of middle-ear effusions; studies of OME and hearing in a Rhesus monkey animal model; and determine a possible genetic component in OME by comparing the concordance rate and consequences of OME on the auditory pathway in twins prospectively followed from birth. During the next grant years, more knowledge will be gained and information disseminated concerning the etiology, pathogenesis, management and prevention of OM.

中耳炎 (OM) 是儿童最常见的疾病 这个国家的医疗保健。 每年花费约20亿美元 关于药物和手术治疗。 80 月 80 日，中耳炎研究 中心设立于匹兹堡儿童医院 专注于五项临床试验和六项实验室/临床研究 人类和动物。 临床试验旨在确定最 管理/预防婴儿和儿童患有此病的有效方法 急性和复发性急性 OM 以及渗出性中耳炎 (OME)。 超过 1,800名受试者已进入临床试验。 减充血剂和 抗组胺药 (D&A) 疗法对 OME 缺乏疗效，但阿莫西林 （不含 D&A）疗法对 OME 有效。 其他功效 抗菌药物（和组合）正在接受测试并将继续进行。 我们的鼓膜切开术和鼓膜切开术（M&T）试验 慢性 OME 表明 M&T 确实可以降低儿童的发病率， 但鼓膜穿孔是一种并发症；最后两年 需要治疗/观察。 预防复发性急性 OM （抗菌剂或 M&T）在使用之前需要进一步治疗/观察 最终结果已知，腺样体切除术联合或不联合扁桃体切除术 （T&A）将需要更多受试者入组和治疗/观察以确定 结果。 抗菌治疗/鼓膜切开术治疗急性 OM 的试验将 按计划完成。 实验室/临床研究包括： 组织学和计算机成像的横截面解剖学和计算机成像 咽鼓管（ET）和颞骨的组织病理学标本； 中耳积液的生化和酶成分； OME研究 恒河猴动物模型的听力；并确定一个可能的 通过比较一致性率和后果来分析 OME 中的遗传成分 OME 对双胞胎听觉通路的影响，从出生起就进行了前瞻性跟踪。 在接下来的资助年里，我们将获得更多的知识和信息 传播有关病因、发病机制、治疗和 预防 OM。