NEW DRUG DEVELOPMENT CLINICAL TRIALS IN SOLID TUMORS

实体瘤新药开发临床试验

• 批准号: 3608361
• 负责人: ALBERT F LO BUGLIO
• 金额: $ 19.06万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-15 至 1986-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3608361
• 关键词: bladder neoplasm; blood chemistry; blood tests; bone neoplasms; breast neoplasms; carcinoembryonal antigen; cervix neoplasms; combination cancer therapy; head /neck neoplasm; histopathology; human subject; human therapy evaluation; kidney neoplasms; lung neoplasms; lymphoma; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; neoplasm /cancer therapy; ovary neoplasms; pancreas neoplasms; prostate neoplasms; sarcoma; stomach neoplasms; testis neoplasms; urinalysis; uterus neoplasms

Furnish all necessary personnel, labor, patients, facilities, equipment, materials, and supplies required to conduct Phase II and Phase III studies in patients with disseminated solid tumors such as: cancers of the lung, breast, prostate, bladder, kidney, testicle, ovary, endometrium, cervix, head and neck, stomach, pancreas, and colon, as well as lymphomas, melanomas, and bone and soft tissue sarcomas. Seventy-five patients are required for the first four month period with 250 patients per year for the next four years. The final year of the contract is for patient treatment and follow-up only. Patients to be studied, accrued, and treated for each tumor type to be dictated by the particular protocols approved.

提供所有必要的人员，人工，患者，设施，设备， 材料以及进行II阶段和第三阶段研究所需的供应 患有散布实体瘤的患者，例如：肺癌，乳房的癌症， 前列腺，膀胱，肾脏，睾丸，卵巢，子宫内膜，子宫颈，头部和颈部， 胃，胰腺和结肠，以及淋巴瘤，黑色素瘤以及骨骼和柔软 组织肉瘤。 前四个月需要75例患者 在接下来的四年中，每年有250名患者。 最后一年 合同仅用于患者治疗和随访。 患者是 对每种肿瘤类型进行研究，应计和处理 批准的特定协议。

项目成果

Phase II trial of methylglyoxal bis (guanylhydrazone) (MGBG) in advanced head and neck cancer.

甲基乙二醛双（脒腙）（MGBG）治疗晚期头颈癌的 II 期试验。

• DOI: 10.1002/1097-0142(19861215)58:12<2585::aid-cncr2820581205>3.0.co;2-2
• 发表时间: 1986
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Forastiere,AA;Natale,RB;Wheeler,RR
• 通讯作者: Wheeler,RR

Phase II trial of methylglyoxal bis-guanylhydrazone (MGBG) in refractory small cell lung cancer.

甲基乙二醛双脒腙 (MGBG) 治疗难治性小细胞肺癌的 II 期试验。

• DOI: 10.1007/bf00171989
• 发表时间: 1990
• 期刊: Investigational new drugs
• 影响因子: 3.4
• 作者: Simon,MS;Eckenrode,J;Natale,RB
• 通讯作者: Natale,RB

Cisplatin, vinblastine, and mitoguazone chemotherapy for epidermoid and adenocarcinoma of the esophagus.

顺铂、长春花碱和米托瓜宗化疗用于治疗食管表皮样癌和腺癌。

• DOI: 10.1200/jco.1987.5.8.1143
• 发表时间: 1987
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Forastiere,AA;Gennis,M;Orringer,MB;Agha,FP
• 通讯作者: Agha,FP

Combination cisplatin and dichloromethotrexate in patients with advanced or recurrent cervical cancer: a preliminary report.

顺铂和二氯甲氨蝶呤联合治疗晚期或复发性宫颈癌：初步报告。

• DOI: 10.1016/0090-8258(84)90180-x
• 发表时间: 1984
• 期刊: Gynecologic oncology
• 影响因子: 4.7
• 作者: Roberts,JA;Morley,GW;Natale,RB;Wheeler,RH
• 通讯作者: Wheeler,RH

Phase II trial of ICRF-187 in non-small cell lung cancer.

ICRF-187治疗非小细胞肺癌的II期试验。

• 发表时间: 1983
• 期刊: Cancer treatment reports
• 作者: Natale,RB;Wheeler,RH;Liepman,MK;Sauder,A;Bricker,L
• 通讯作者: Bricker,L